Results 121 to 130 of about 468,292 (298)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Limited open repair for achilles tendon rupture in the setting of co-morbidities: A case series and technique review

Foot & Ankle Surgery: Techniques, Reports & Cases
An acute Achilles tendon rupture poses a difficult treatment strategy in both young and old patients. Commonly considered an injury of the middle aged “weekend warrior,” an Achilles tendon tear in a sedentary patient is quite debilitating.
James C. Connors, DPM, FACFAS, Mark A. Hardy, DPM, FACFAS, Halle L. Krebs, Ali A. Manji, DPM, Cory M. Jarosi, DPM   +4 more
doaj   +1 more source

RIGID INDEPENDENCE

, 2018
We extend the notion of independent sets to rigid independent sets. We choose the term {\em rigid} instead of {\em stable} since it reflects the rigidity of a block of concrete rather than the stability of a standing block.
openaire   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Background of the Revolution for Mexican Independence.

, 1935
W. H. Callcott, Lillian Estelle Fisher
openalex   +2 more sources

On the characterisation of the normal population by the independence of the sample mean and the sample variance. [PDF]

, 1949
Tatsuo Kawata, Heihati SAKAMOTO
openalex   +1 more source

Solitaire of independence

Natural Computing
Abstract In this paper, we study a reversible process (more precisely, a groupoid/group action) resembling the classical 15-puzzle, where the legal moves are to “move the unique hole inside a translate of a shape S”. Such a process can be defined for any finite subset S of a group, and we refer to such a process as simply “solitaire”.
Ville Salo, Juliette Schabanel
openaire   +2 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Comparison of Omron and ActiGraph monitors in estimating daily step counts and time spent in moderate to vigorous physical activity in free-living adults

BMJ Open Sport & Exercise Medicine
Objective This study compared the Omron Active style Pro HJA-750C (OM) and the ActiGraph wGT3X-BT (AG) in estimating daily physical activity—step counts and time spent in moderate to vigorous physical activity (MVPA)—in free-living adults.Methods ...
Kazushi Maruo, Hiroyuki Sasai, Hiroko Shimura, Shinpei Okada, Kaori Daimaru, Naoki Deguchi, Yoshinori Fujiwara   +6 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source