Results 101 to 110 of about 948,462 (255)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Sex-specific factors associated with acceptance of smartwatches among urban older adults: the Itabashi longitudinal study on aging

Frontiers in Public Health
Smartwatches (SW) are wearable devices that support daily life and monitor an individual’s health and activity status. This information is utilized to promote behavior modification, which could help prevent chronic diseases and manage the health of older
Naoki Deguchi, Yosuke Osuka, Yosuke Osuka, Narumi Kojima, Keiko Motokawa, Masanori Iwasaki, Hiroki Inagaki, Fumiko Miyamae, Tsuyoshi Okamura, Hirohiko Hirano, Shuichi Awata, Hiroyuki Sasai   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

1925 catalogue of the Independence Nurseries, landscape gardeners and general nurserymen, water lilies and fancy fish

, 1925
192
Buskirk, A. S., Henry G. Gilbert Nursery and Seed Trade Catalog Collection., Independence Nurseries (Independence, Ohio)   +2 more
core   +1 more source

Community Social Capital and All-cause Mortality in Japan: Findings From the Adachi Cohort Study

Journal of Epidemiology
Background: Community social capital is associated with various health outcomes; however, its impact on mortality is not fully understood, particularly in non-Western settings.
Hiroshi Murayama, Mika Sugiyama, Hiroki Inagaki, Ayako Edahiro, Fumiko Miyamae, Chiaki Ura, Keiko Motokawa, Tsuyoshi Okamura, Shuichi Awata   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Catalogue of Independence Nurseries, landscape gardeners and general nurserymen, waterlilies, and fancy fishes

, 1920
192
Buskirk, A. S., Henry G. Gilbert Nursery and Seed Trade Catalog Collection., Independence Nurseries (Independence, Ohio)   +2 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source