Results 251 to 260 of about 3,085,836 (327)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Functional Independence Measure assessed early after admission predicts home discharge in older adults admitted to acute general medical wards: a retrospective cohort study. [PDF]

Fam Med Community Health
Kakehi E, Matsumoto Y, Namura K, Sugiyama K, Akamatsu Y, Sakurai S, Nozaki T, Shoji K, Adachi S, Kotani K.   +9 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Associations between technology use, perceived burdensomeness, and independence among rural older adults. [PDF]

BMC Geriatr
Bal B, Apaydin E.
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Post-discharge outcome measurement tools in occupational therapy for people with acquired brain injury in Japan: a scoping review. [PDF]

PeerJ
Oyama N, Aoki S, Williams-Macklin T, Bateman A.   +3 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Autonomization of Microvascular Free Flaps in Reconstructive Surgery: A Narrative Review. [PDF]

Microsurgery
Wüster J, Knoedler L, Niederegger T, Brandenburg LS, Hundeshagen G, Heiland M, Koerdt S.   +6 more
europepmc   +1 more source

An AI-powered research assistant in the lab: A practical guide for text analysis through iterative collaboration with LLMs. [PDF]

Behav Res Methods
Carmona-Díaz G, Jiménez-Leal W, Grisales MA, Sripada C, Amaya S, Inzlicht M, Bermúdez JP.   +6 more
europepmc   +1 more source

The potential benefits of transcranial magnetic stimulation combined with reminiscence therapy on cognitive function in patients with stroke. [PDF]

Open Med (Wars)
Dai R, Wang F.
europepmc   +1 more source