Results 71 to 80 of about 468,292 (298)
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Feasibility and Effectiveness of Telehealth Occupational Therapy Home Modification Interventions
International Journal of Telerehabilitation, 2018 Despite the effectiveness of occupational therapy home modification interventions, persons with disabilities may not receive them due to service delivery costs, limited number of therapists, and expansive geographic service areas.
Marnie Renda, Jennifer E. Lape
doaj +1 more source
A Reflection on the Independence of Independent Agencies
Duke Law Journal, 1988 Independent agencies should not be independent. I believe that for policy as well as for constitutional reasons. When I was Chairman of the Federal Trade Commission (FTC), I often posed to myself the following question: "To whom am I accountable?" Often, it seemed, the answer would be: "To 435 Congressmen, 100 Senators, and the President himselfl" On ...
C James, Miller
openaire +2 more sources
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
On Independence Domination [PDF]
, 2013 Let G be a graph. The independence-domination number is the maximum over all independent sets I in G of the minimal number of vertices needed to dominate I. In this paper we investigate the computational complexity of independence domination for graphs in several graph classes related to cographs. We present an exact exponential algorithm.
Hsiang-Hsuan Liu +4 more
openaire +3 more sources
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Assessing the influence of fiscal and monetary policies on carbon dioxide emissions
Latin American Journal of Central BankingThis paper examines the impact of fiscal and monetary policies on carbon dioxide emissions in Trinidad and Tobago, using data from 1970 to 2020. We use a fiscal policy index based on government revenue and expenditure, a monetary policy index based on ...
Avinash Ramlogan, Andell Nelson
doaj +1 more source
Independent Judges and Independent Justice [PDF]
Law and Contemporary Problems, 1998 American judges come from a long tradition of judicial independence, even when the formal British regime curtailed that independence. For example, English judges had no independence before 1701-and not much after that date. There was no practice of judicial review; judges did not strike down legislative enactments.
openaire +2 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source