Results 81 to 90 of about 2,486,152 (319)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

On Statistical Independence and Density Independence

open access: yesTatra Mountains Mathematical Publications
Abstract In the first part we recall the notion of statistical independence. The second part is devoted to the definition of selective density and its connection with the distribution of sequences. Then we define the independence of sequences with respect to selective density.
openaire   +2 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Complete mitogenome of the ixodid tick Dermacentor reticulatus (Acari: Ixodida)

open access: yesMitochondrial DNA. Part B. Resources, 2020
Here, we present the complete mitochondrial DNA sequence of Dermacentor reticulatus. The mitogenome is 14,806 bp and contains 13 protein-coding, 2 rRNA, and 22 tRNA genes, along with 2 control regions.
Mikhail Yu Kartashov   +6 more
doaj   +1 more source

Bilateralism, Independence and Coordination [PDF]

open access: yes, 2018
Bilateralism is a theory of meaning according to which assertion and denial are independent speech acts. Bilateralism also proposes two coordination principles for assertion and denial.
Santos, Gonçalo
core  

A Reflection on the Independence of Independent Agencies

open access: yesDuke Law Journal, 1988
Independent agencies should not be independent. I believe that for policy as well as for constitutional reasons. When I was Chairman of the Federal Trade Commission (FTC), I often posed to myself the following question: "To whom am I accountable?" Often, it seemed, the answer would be: "To 435 Congressmen, 100 Senators, and the President himselfl" On ...
C James, Miller
openaire   +2 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Feasibility and Effectiveness of Telehealth Occupational Therapy Home Modification Interventions

open access: yesInternational Journal of Telerehabilitation, 2018
Despite the effectiveness of occupational therapy home modification interventions, persons with disabilities may not receive them due to service delivery costs, limited number of therapists, and expansive geographic service areas.
Marnie Renda, Jennifer E. Lape
doaj   +1 more source

Independent Judges and Independent Justice [PDF]

open access: yesLaw and Contemporary Problems, 1998
American judges come from a long tradition of judicial independence, even when the formal British regime curtailed that independence. For example, English judges had no independence before 1701-and not much after that date. There was no practice of judicial review; judges did not strike down legislative enactments.
openaire   +2 more sources

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