Results 61 to 70 of about 651,740 (292)

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Apakah Integritas Memodersi Kecerdasan Emosional, Kompetensi dan Independensi terhadap Kualitas Audit?

Jurnal Akademi Akuntansi
Purpose: This study aims to analyze the influence of emotional quotient, competence, and independence, by involving auditor integrity as a moderating influence on audit quality. Methodology/approach: The population in this study consists of all levels
Yulia Monica Ristanti, Sutrisno Sutrisno, Sari Atmini   +2 more
doaj   +1 more source

Entropic Measure of Epistemic Uncertainties in Multibody System Models by Axiomatic Design

Entropy, 2017
In this paper, the use of the MaxInf Principle in real optimization problems is investigated for engineering applications, where the current design solution is actually an engineering approximation.
Francesco Villecco, Arcangelo Pellegrino
doaj   +1 more source

Phenotype-based probabilistic analysis of heterogeneous responses to cancer drugs and their combination efficacy.

PLoS Computational Biology, 2020
Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity.
Natacha Comandante-Lou, Mehwish Khaliq, Divya Venkat, Mohan Manikkam, Mohammad Fallahi-Sichani   +4 more
doaj   +1 more source

Lognormal scale invariant random measures

, 2012
In this article, we consider the continuous analog of the celebrated Mandelbrot star equation with lognormal weights. Mandelbrot introduced this equation to characterize the law of multiplicative cascades.
B. Castaing, B. Castaing, B.B. Mandelbrot, D. Applebaum, E. Bacry, E. Bacry, F. Schmitt, G. Stolovitzky, I. Benjamini, I.M. Gelfand, J. Barral, J.-P. Kahane, L. Schwartz, R. Rhodes, R. Robert, Romain Allez, Rémi Rhodes, U. Frisch, V.G. Knizhnik, Vincent Vargas   +19 more
core   +1 more source

Probability with Martingales

Cambridge mathematical textbooks, 1991
1. A branching-process example Part I. Foundations: 2. Measure spaces 3. Events 4. Random variables 5. Independence 6. Integration 7. Expectation 8. An easy strong law: product measure Part II. Martingale Theory: 9.
David Williams
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

A Nonstochastic Information Theory for Communication and State Estimation

, 2014
In communications, unknown variables are usually modelled as random variables, and concepts such as independence, entropy and information are defined in terms of the underlying probability distributions.
Nair, Girish N.
core   +1 more source