Results 61 to 70 of about 511,438 (289)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Research on a Three-Way Decision-Making Approach, Based on Non-Additive Measurement and Prospect Theory, and Its Application in Aviation Equipment Risk Analysis

Entropy
Due to the information non-independence of attributes, combined with a complex and changeable environment, the analysis of risks faces great difficulties. In view of this problem, this paper proposes a new three-way decision-making (3WD) method, combined
Ruicong Xia, Sirong Tong, Qiang Wang, Bingzhen Sun, Ziling Xu, Qiuhan Liu, Jiayang Yu, Fan Wu   +7 more
doaj   +1 more source

Distance covariance in metric spaces

, 2013
We extend the theory of distance (Brownian) covariance from Euclidean spaces, where it was introduced by Sz\'{e}kely, Rizzo and Bakirov, to general metric spaces. We show that for testing independence, it is necessary and sufficient that the metric space
Lyons, Russell
core   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Impact Assessment of the Implementation of Sustainability Practices on the Competitiveness of Moroccan Companies: Insights From the (Enterprise Surveys)

Climate Resilience and Sustainability
This study examines how sustainability practices affect the external competitiveness of Moroccan manufacturing firms. Drawing on stakeholder theory, the resource‐based view, and institutional theory, sustainability is operationalized through two ...
Otman Chahbi, Mohamed Belafhaili, Taoufik Benkaraache, Imane Rabhi   +3 more
doaj   +1 more source

Entropic Measure of Epistemic Uncertainties in Multibody System Models by Axiomatic Design

Entropy, 2017
In this paper, the use of the MaxInf Principle in real optimization problems is investigated for engineering applications, where the current design solution is actually an engineering approximation.
Francesco Villecco, Arcangelo Pellegrino
doaj   +1 more source

Phenotype-based probabilistic analysis of heterogeneous responses to cancer drugs and their combination efficacy.

PLoS Computational Biology, 2020
Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity.
Natacha Comandante-Lou, Mehwish Khaliq, Divya Venkat, Mohan Manikkam, Mohammad Fallahi-Sichani   +4 more
doaj   +1 more source

A Nonstochastic Information Theory for Communication and State Estimation

, 2014
In communications, unknown variables are usually modelled as random variables, and concepts such as independence, entropy and information are defined in terms of the underlying probability distributions.
Nair, Girish N.
core   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Lognormal scale invariant random measures

, 2012
In this article, we consider the continuous analog of the celebrated Mandelbrot star equation with lognormal weights. Mandelbrot introduced this equation to characterize the law of multiplicative cascades.
B. Castaing, B. Castaing, B.B. Mandelbrot, D. Applebaum, E. Bacry, E. Bacry, F. Schmitt, G. Stolovitzky, I. Benjamini, I.M. Gelfand, J. Barral, J.-P. Kahane, L. Schwartz, R. Rhodes, R. Robert, Romain Allez, Rémi Rhodes, U. Frisch, V.G. Knizhnik, Vincent Vargas   +19 more
core   +1 more source