Results 41 to 50 of about 515,753 (286)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Reliability analysis for high-lift device based on Copula function and Bayesian updating

Advances in Mechanical Engineering, 2018
In order to improve the reliability analysis accuracy of the aircraft high-lift, an approach based on the Copula function theory and Bayesian updating is proposed. Considering the influence of the random variables’ correlation in the process of updating,
Jiazhen Feng, Jianguo Zhang, Jiwei Qiu
doaj   +1 more source

Volumes of Restricted Minkowski Sums and the Free Analogue of the Entropy Power Inequality

, 1995
In noncommutative probability theory independence can be based on free products instead of tensor products. This yields a highly noncommutative theory: free probability .
A.J. Stam, D. Voiculescu, D. Voiculescu, Dan Voiculescu, E.A. Carlen, G. Pisier, H.J. Brascamp, N.M. Blachman, R. Schneider, Stanislaw J. Szarek   +9 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Quantum signatures of chaos from free probability

Journal of High Energy Physics
A classical dynamical system can be viewed as a probability space equipped with a measure-preserving time evolution map, admitting a purely algebraic formulation in terms of the algebra of bounded functions on the phase space.
Hugo A. Camargo, Yichao Fu, Viktor Jahnke, Keun-Young Kim, Kuntal Pal   +4 more
doaj   +1 more source

Modeling Unpredictable Behavior of Energy Facilities to Ensure Reliable Operation in a Cyber-Physical System

Energies, 2023
This research focuses on exploring various techniques and models for simulating the random behavior of energy facilities or systems. These simulations are essential in identifying the likelihood of component failures within the studied facilities.
Ivan Postnikov, Ekaterina Samarkina, Andrey Penkovskii, Vladimir Kornev, Denis Sidorov   +4 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Volcanic hazard assessment for the Canary Islands (Spain) using extreme value theory [PDF]

Natural Hazards and Earth System Sciences, 2011
The Canary Islands are an active volcanic region densely populated and visited by several millions of tourists every year. Nearly twenty eruptions have been reported through written chronicles in the last 600 yr, suggesting that the probability of a new ...
R. Sobradelo, J. Martí, A. T. Mendoza-Rosas, G. Gómez   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Information Structures for Causally Explainable Decisions

Entropy, 2021
For an AI agent to make trustworthy decision recommendations under uncertainty on behalf of human principals, it should be able to explain why its recommended decisions make preferred outcomes more likely and what risks they entail.
Louis Anthony Cox
doaj   +1 more source