Results 61 to 70 of about 515,753 (286)

Distance covariance in metric spaces

, 2013
We extend the theory of distance (Brownian) covariance from Euclidean spaces, where it was introduced by Sz\'{e}kely, Rizzo and Bakirov, to general metric spaces. We show that for testing independence, it is necessary and sufficient that the metric space
Lyons, Russell
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Impact Assessment of the Implementation of Sustainability Practices on the Competitiveness of Moroccan Companies: Insights From the (Enterprise Surveys)

Climate Resilience and Sustainability
This study examines how sustainability practices affect the external competitiveness of Moroccan manufacturing firms. Drawing on stakeholder theory, the resource‐based view, and institutional theory, sustainability is operationalized through two ...
Otman Chahbi, Mohamed Belafhaili, Taoufik Benkaraache, Imane Rabhi   +3 more
doaj   +1 more source

Entropic Measure of Epistemic Uncertainties in Multibody System Models by Axiomatic Design

Entropy, 2017
In this paper, the use of the MaxInf Principle in real optimization problems is investigated for engineering applications, where the current design solution is actually an engineering approximation.
Francesco Villecco, Arcangelo Pellegrino
doaj   +1 more source

Phenotype-based probabilistic analysis of heterogeneous responses to cancer drugs and their combination efficacy.

PLoS Computational Biology, 2020
Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity.
Natacha Comandante-Lou, Mehwish Khaliq, Divya Venkat, Mohan Manikkam, Mohammad Fallahi-Sichani   +4 more
doaj   +1 more source

Investigation of commuting Hamiltonian in quantum Markov network

, 2014
Graphical Models have various applications in science and engineering which include physics, bioinformatics, telecommunication and etc. Usage of graphical models needs complex computations in order to evaluation of marginal functions,so there are some ...
Babazadeh, Mohammad, Bayramzadeh, Rogayeh, Jouneghani, Farzad Ghafari, Movla, Hossein   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The Optimal Confidence Intervals for Agricultural Products’ Price Forecasts Based on Hierarchical Historical Errors

Entropy, 2016
With the levels of confidence and system complexity, interval forecasts and entropy analysis can deliver more information than point forecasts. In this paper, we take receivers’ demands as our starting point, use the trade-off model between accuracy and ...
Yi Wang, Xin Su, Shubing Guo
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source