Results 81 to 90 of about 4,385,567 (281)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
A Feature-Selective Independent Component Analysis Method for Functional MRI
International Journal of Biomedical Imaging, 2007 In this work, we propose a simple and effective scheme to incorporate prior knowledge about the sources of interest (SOIs) in independent component analysis (ICA) and apply the method to estimate brain activations from functional magnetic resonance ...
Yi-Ou Li, Tülay Adali, Vince D. Calhoun
doaj +1 more source
Independent component analysis based on quantum particle swarm optimization
Egyptian Informatics Journal, 2018 One of the Digital Signal Processing problems is a Blind Source Separation (BSS). There are some of methods are employed to solve this problem which are so-called Independent Component Analysis (ICA) which based on the statistical distribution of the ...
Nidaa AbdulMohsin Abbas +1 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Identifying Rodent Resting-State Brain Networks with Independent Component Analysis
Frontiers in Neuroscience, 2017 Rodent models have opened the door to a better understanding of the neurobiology of brain disorders and increased our ability to evaluate novel treatments.
Dusica Bajic +12 more
doaj +1 more source
Macroeconomic Forecasting with Independent Component Analysis [PDF]
This paper considers a factor model in which independent component analysis (ICA) is employed to construct common factors out of a large number of macroeconomic time series. The ICA has been regarded as a better method to separate unobserved sources that
Ruey Yau
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
An efficient quantum algorithm for independent component analysis
New Journal of PhysicsIndependent component analysis (ICA) is a fundamental data processing technique to decompose the captured signals into as independent as possible components.
Xiao-Fan Xu +5 more
doaj +1 more source