Results 81 to 90 of about 27,482,395 (244)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating human audio-visual object perception with a combination of hypothesis-generating and hypothesis-testing fMRI analysis tools [PDF]

, 2011
Primate multisensory object perception involves distributed brain regions. To investigate the network character of these regions of the human brain, we applied data-driven group spatial independent component analysis (ICA) to a functional magnetic ...
van den Bosch, Jasper J F, Wolf Singer, van den Bosch, J.J.F., Kohler, A., Kaiser, J., Kaiser, Jochen, Ven, Vincent van de, Marcus J. Naumer, Bosch, Jasper J. F. van den, van de Ven, Vincent, Lars Muckli, Muckli, L., Kohler, Axel, Singer, Wolf, Axel Kohler, Jochen Kaiser, Naumer, M.J., van den Bosch, J., Muckli, Lars, Wibral, M., Wibral, Michael, Michael Wibral, Jasper J. F. van den Bosch, Naumer, Marcus Johannes, Vincent van de Ven, Naumer, Marcus J, van de Ven, V., Singer, W., Muckli, L, van, de Ven V, Naumer, MJ, Wibral, M, van den Bosch, Jasper JF; id_orcid, Kohler, A   +33 more
core   +2 more sources

Ranking and averaging independent component analysis by reproducibility (RAICAR)

, 2008
Independent component analysis (ICA) is a data-driven approach that has exhibited great utility for functional magnetic resonance imaging (fMRI). Standard ICA implementations, however, do not provide the number and relative importance of the resulting ...
LaConte, Stephen, Hu, Xiaoping, Weng, Xuchu, X. P. Hu, Yang, Zhi   +4 more
core   +1 more source

Extraction of drum tracks from polyphonic music using independent subspace analysis

, 2022
843848The analysis and separation of audio signals into their original components is an important prerequisite to automatic transcription of music, extraction of metadata from audio data, and speaker separation in video conferencing.
Uhle, C., Sporer, T., Dittmar, C.
core   +1 more source

A novel fixed-point algorithm for constrained independent component analysis

EURASIP Journal on Advances in Signal Processing, 2019
Constrained independent component analysis (ICA) is an effective method for solving the blind source separation with a prior knowledge. However, most constrained ICA algorithms are proposed for the real-valued sources.
Guobing Qian, Lidan Wang, Shiyuan Wang, Shukai Duan   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Leaf vein extraction using independent component analysis [PDF]

, 2006
The purpose of this work is to develop an interactive tool which helps botanists to extract the vein system with its hierarchical properties with as little user interaction as possible.
David D. Feng, Chi, Zheru, Feng, D, Feng, David, Li, Y, Li, Yan, Zheru Chi, Chi, Z, Yan Li   +8 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Independent component analysis for multivariate functional data

, 2020
We extend two methods of independent component analysis, fourth order blind identification and joint approximate diagonalization of eigen-matrices, to vector-valued functional data.
Oja, Hannu, Virta, Joni, Li, Bing, Nordhausen, Klaus   +3 more
core   +1 more source