Results 71 to 80 of about 7,147,780 (265)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Cross-cultural adaptation and reliability evaluation of the Lithuanian version of the keys questionnaire [PDF]
, 2021 The aim of this study is the KEYS questionnaire cross-cultural adaptation into the Lithuanian language. This study was designed to translate and perform cultural adaptation as well as test the reliability of the Lithuanian version of the KEYS ...
Ganusauskaitė, Aurelija +1 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 1995 "[T]he [Coquille Indian] Tribe requested that the State of Oregon assemble a team of independent scientists to peer review the forest management strategy proposed by the ISAT.
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Boyle And Camps Written Evidence Independent Review of Administrative Law 19 Oct 2020 [PDF]
, 2020 1.1. The exercise of power by the executive does not occur in a vacuum. It forms part of a broader constitutional framework whereby executive power is vested in government and the government and all those exercising power on behalf of the state must ...
Camps, Diana, Boyle, Katie
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This paper presents an architectural project for a cultural center featuring permanent exhibitions in homage to José Bonifácio de Andrada e Silva, the patron of Brazilian independence. The facility is situated in the historic center of Santos, São Paulo, Brazil, on the site encompassing the Arcos do Valongo, a protected historic gable designated by the
Silva, João Pedro +2 more
openaire +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
BCC presents 1984-85 cultural arts series
, 2010 Fall Semester posting of the Cultural Arts Series; Spring Semester posting of the Cultural Arts Series.Various events posted for the Black Cultural Center’s Cultural Arts Series of 1984-85.Photos of Phyllis Hyman and Alvin Poussaint included along with a
Purdue University. Black Cultural Center;
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