Results 31 to 40 of about 847,681 (313)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Journal of CMEThere was a renewed vigour among the participants attending the 16th Annual European CME Forum (#16ECF), which took place in the Hague, the Netherlands from 8–10 November 2023.
Ron Murray, Cara L. Macfarlane
doaj +1 more source
Infographics and independent learning for English learning in the secondary level context
Journal on English as a Foreign Language, 2021 Visual media are still ineffective in covering all learning focus and learning activities to support independent learning. Independent learning guides students to learn the material by themselves, but it is still not supported by the existing visual ...
Fiorentina Dewantari +2 more
doaj +1 more source
Learning to Predict Independent of Span
CoRR, 2015 32 ...
Hado van Hasselt, Richard S. Sutton
openaire +2 more sources
Learning from Pairwise Marginal Independencies [PDF]
CoRR, 2015 10 pages, 6 figures, 2 tables. Published at the 31st Conference on Uncertainty in Artificial Intelligence (UAI 2015)
Textor, Johannes +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Characterization of NMDAR-Independent Learning in the Hippocampus [PDF]
Frontiers in Behavioral Neuroscience, 2011 It is currently thought that memory formation requires the activation of NMDA receptors (NMDARs) in the hippocampus. However, recent studies indicate that these receptors are not necessary for all forms of learning. The current experiments examine this issue using context fear conditioning in mice.
Tayler, Kaycie Kuss +6 more
openaire +3 more sources
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Behavioral SciencesThis meta-analysis reports on the effect of professional development (PD) on K-12 in-service STEM teachers’ self-efficacy. There were 18 selected empirical studies in this study. Overall, PD had a modest positive effect on self-efficacy (Hedges’g = 0.551,
Jiao Liu, Ke Wang, Zilong Pan
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source