Results 121 to 130 of about 3,030,309 (307)

IMProving older people’s health through physical ACTivity: the implementation of a community-based framework to promote park-based active ageing

BMC Public Health
Background Outdoor environments such as recreational spaces with age-friendly exercise equipment offer promising and sustainable approaches to promote physical activity among older people.
Pazit Levinger, Marcia Fearn, Bronwyn Dreher, Adrian Bauman, Sze-Ee Soh, Natasha K. Brusco, Andrew Gilbert, Rachel Muoio, Elissa Burton, Keith Hill   +9 more
doaj   +1 more source

Roadmap For Ethical Product Certification and Standard Setting Initiatives [PDF]

, 2009
The International Labor Rights Forum has developed a set of certification standards with the goal of addressing the root causes of factory and farm sweatshop conditions in global supply chains.
International Labor Rights Forum
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Enhancing health and independent living for veterans with disabilities by leveraging community-based resources

Journal of Multidisciplinary Healthcare, 2017
Jennifer Hale-Gallardo,1 Huanguang Jia,1 Tony Delisle,2 Charles E Levy,1,3–5 Valentina Osorio,1 Jennifer A Smith,1 Elizabeth M Hannold,1,† 1Center of Innovation on Disability and Rehabilitation Research, North Florida/South Georgia Veterans ...
Hale-Gallardo J, Jia H, Delisle T, Levy CE, Osorio V, Smith JA, Hannold EM   +6 more
doaj  

The Significance of Non-ergodicity Property of Statistical Mechanics Systems for Understanding Resting State of a Living Cell [PDF]

, 2010
A better grasp of the physical foundations of life is necessary before we can understand the processes occurring inside a living cell. In his physical theory of the cell, American physiologist Gilbert Ling introduced an important notion of the resting ...
Matveev, V. V., Prokhorenko, D. V.
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Int J Geriatr Psychiatry [PDF]

, 2015
ObjectiveThe objective of the study was to compare the predictive utility of three commonly used functioning measures for people with serious mental illness in the prediction of independent living status.MethodsWe conducted a secondary data analysis from
Sušanj, Filip
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Making Bank Notes Accessible for Canadians Living with Blindness or Low Vision [PDF]

The ability to conduct financial transactions using bank notes is crucial to independent living. Yet this can pose significant challenges for individuals who are blind or partially sighted.
Carolyn Samuel
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