Results 101 to 110 of about 6,147,251 (299)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The potential of information and communication technologies to support ageing and independent living

, 2010
This paper discusses the potential of ICT (Information and Communications Technology) to support ageing and independent living. It reports on the expected impact of ageing Baby Boomers, the environment for ageing, chronic illness and other challenges of ...
Soar, Jeffrey
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

5-Year Plan for Independent Living in Texas

, 1991
Report that includes the progress of he plan, purpose of the revised plan, and outlines the goals and strategies of the 5 year plan for independent living in ...
Texas. State Living Council.
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Preliminary Study of the Immediate Effects of Spherical-Grip and Palmar-Support Handwriting Assistive Devices on Handwriting Kinematics During Numeric Copying in Children with Disabilities

Children
Background: Children with disabilities may experience difficulty with handwriting due to motor impairments that limit their ability to grasp and manipulate a pen.
Seong Ho Yun, Seon-Deok Eun
doaj   +1 more source

20 years of Personal Assistance in Sweden [Elektronisk resurs] : What constitutes preconditions for independent living?

, 2015
Background The Swedish Act regarding Support and Service for Persons with Certain Functional Impairments (LSS), in effect since 1994, guarantees good living conditions for the users and covers a wide range of user groups with regard to age, disability ...
von Granitz, Helene,
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

‘Changing the Focus’: Co-Design of a Novel Approach for Engaging People with Dementia in Physical Activity

Nursing Reports
Background: Promoting physical activity among people living with dementia is critical to maximise physical, cognitive and social benefits; yet the lack of knowledge, skills and confidence among health professionals, informal care partners and people with
Claudia Meyer, Den-Ching A. Lee, Michele Callisaya, Morag E. Taylor, Katherine Lawler, Pazit Levinger, Susan Hunter, Dawn C. Mackey, Elissa Burton, Natasha Brusco, Terry Haines, Christina L. Ekegren, Amelia Crabtree, Keith D. Hill   +13 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source