Results 81 to 90 of about 6,147,251 (299)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

State Plan for Independent Living (SPIL) for Idaho for 2017-2019

, 2016
Idaho State Independent Living Council plan for FY 2017 ...
State Independent Living Council (SILC), Idaho;
core  

Older adults, falls and technologies for independent living: a life space approach [PDF]

, 2011
This paper draws attention to the need for further understanding of the fine details of routine and taken-for-granted daily activities and mobility. It argues that such understanding is critical if technologies designed to mitigate the negative impacts ...
FORAN, TIMOTHY G., CATHY BAILEY, BEN DROMEY, Bailey, Cathy, NI SCANAILL, CLIODHNA, Foran, Timothy, Scanaill, Cliodhna, Dromey, Ben, CLIODHNA NI SCANAILL, TIMOTHY G. FORAN   +9 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Fiscal Year 2010 Monitoring Report on the Vocational Rehabilitation and Independent Living Programs in the State of Idaho

, 2010
Idaho State Independent Living Council report for FY ...
State Independent Living Council (SILC), Idaho;
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Innovative Detachable Two-Way Wheelchair Propulsion System: Enhancing Mobility and Exercise for Spinal Cord Injury Users

Applied Sciences
Background: Prolonged manual wheelchair usage often leads to musculoskeletal disorders in the upper body of individuals with spinal cord injury (SCI) due to repetitive, unidirectional movements.
Jiyoung Park, Eunchae Kang, Seon-Deok Eun, Dongheon Kang   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Four million COVID-19 cases in four European cross-border regions reveal minimal cross-border transmission effect on domestic burden: space-time cluster analysis

BMC Infectious Diseases
Introduction Restrictions of cross-border mobility were used during the COVID-19 pandemic to slow down transmission between countries. Such restrictions came with significant societal costs, and their effect on in-country burdens of COVID-19 has been ...
Brigitte van der Zanden, Boris Kauhl, Volker Hackert, Christian JPA Hoebe   +3 more
doaj   +1 more source