Results 61 to 70 of about 6,849,687 (305)

Navigating entry into higher education: the transition to independent learning and living

Journal of Further and Higher Education, 2021
Student transition into higher education can set the foundation for success at university. However, some students, perhaps in increasing numbers, find this transition difficult.
Miles Thompson, C. Pawson, Bethan Evans
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transportation Patterns of Adults With Travel-Limiting Disabilities in Rural and Urban America

Frontiers in Rehabilitation Sciences, 2022
IntroductionLack of transportation is a significant barrier to community participation for many disabled adults. Living in a rural area introduces additional transportation barriers, such as having to travel long distances to access services or socialize,
Andrew Myers, Catherine Ipsen, Krys Standley   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Using Telehealth to Optimize Healthy Independent Living for Older Adults: A Feasibility Study

Geriatric Nursing, 2018
The purpose of this study was to test feasibility of the Telehealth Community Health Assistance Team (T‐CHAT), a nurse‐led intervention delivered through a telepresence robot designed to promote healthy independent living among older adults.
T. Bakas, D. Sampsel, Jahmeel Israel, Ameya Chamnikar, Barbara Bodnarik, John Greer Clark, Megan Gresham Ulrich, D. Vanderelst   +7 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

What is the cost of equity in assistive technology? A tool for calculating assistive products and services

Frontiers in Rehabilitation Sciences
This paper aims to address a technical conundrum in accurately costing and delivering assistive products and services in the context of market-shaping strategies designed to promote assistive technology (AT) access.
Natasha Layton, Em Bould, Libby Callaway, Libby Callaway, Emma Friesen Osborne, Emma Friesen Osborne, Natasha Brusco   +6 more
doaj   +1 more source

Successful Leisure in Independent Living Communities: Understanding Older Adults' Motivations to Engage in Leisure Activities

International Conference on Human Factors in Computing Systems, 2017
Leisure activities are a source of meaning and enjoyment for individuals across the lifespan. In this study, we conducted interviews with twenty-four older adults living in four different independent living communities. We present societal and ecological
Amanda Lazar, David H. Nguyen
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A prospective, observational, cost of implementation analysis for the National Infection Surveillance Program for Aged Care (NISPAC)

Antimicrobial Resistance and Infection Control
Background The National Infection Surveillance Program for Aged Care (NISPAC) is a new standardised and streamlined infection and antimicrobial use surveillance tool for Australian Residential Aged Care Homes (RACHs). As a part of the program development
Natasha Brusco, Sara Whittaker, Karin Thursky, David Dunt, Janet K. Sluggett, Ann Bull, Leon J. Worth, Noleen Bennett   +7 more
doaj   +1 more source