Results 91 to 100 of about 3,030,309 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Internal migration and household living conditions in Ethiopia [PDF]

Using the 1998 Migration, Gender and Health Survey in Five Regions of Ethiopia, and multivariate regression techniques, this paper examines the relationship between internal migration and household living conditions. The analysis finds significant living
Blessing Mberu
core  

Moving into Adulthood: Implementation Findings from the Youth Villages Transitional Living Evaluation [PDF]

, 2014
The Youth Villages Transitional Living program is intended to help youth who were formerly in foster care or juvenile justice custody, or who are otherwise unprepared for adult life, to make the transition to independent living.
Erin Jacobs, Julianna Alson, Melanie Skemer, Michelle Manno   +3 more
core  

Four million COVID-19 cases in four European cross-border regions reveal minimal cross-border transmission effect on domestic burden: space-time cluster analysis

BMC Infectious Diseases
Introduction Restrictions of cross-border mobility were used during the COVID-19 pandemic to slow down transmission between countries. Such restrictions came with significant societal costs, and their effect on in-country burdens of COVID-19 has been ...
Brigitte van der Zanden, Boris Kauhl, Volker Hackert, Christian JPA Hoebe   +3 more
doaj   +1 more source

Living Independently [PDF]

, 2017
Objectives:\ud The aim of this study is to gain a deeper understanding of the experiences of visually impaired older people living independently at home.\ud \ud Background:\ud As populations are aging globally, there is now an increase in the prevalence of visual impairment.
Rooney, C., Hadjri, K., Faith, V., Rooney, M., McAllister, K., Craig, C.   +5 more
openaire  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Home modifications: important for fall injury prevention for Māori in New Zealand

The Lancet Public Health, 2021
Keith D Hill
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Transition to Independent Living for Young Adults with Intellectual Disability: A Scoping Review

Scandinavian Journal of Disability Research
Background: The transition to adulthood represents a pivotal period for young adults with intellectual disabilities. Yet limited research exists on how their lived experiences align with the right to independent living as enshrined in Article 19 of the ...
Iselin Evensen, Line Melboe, Anita Borch
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source