Results 91 to 100 of about 6,147,251 (299)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Home modifications: important for fall injury prevention for Māori in New Zealand

The Lancet Public Health, 2021
Keith D Hill
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

SCSILC Policy Statement: Medical Rationing

, 2020
“Medical rationing” is the practice of subjectively determining who receives medical care. The South Carolina Statewide Independent Living Council (SCSILC) opposes the discriminatory practice of medical ...
South Carolina Statewide Independent Living Council
core   +1 more source

Correction to: Self-managed occupational therapy and physiotherapy for adults receiving inpatient rehabilitation (‘My Therapy’): protocol for a stepped-wedge cluster randomised trial

BMC Health Services Research, 2021
Natasha K. Brusco, Christina L. Ekegren, Nicholas F. Taylor, Keith D. Hill, Annemarie L. Lee, Lisa Somerville, Natasha A. Lannin, Derick Wade, Rania Abdelmotaleb, Libby Callaway, Sara L. Whittaker, Meg E. Morris   +11 more
doaj   +1 more source

Transition to Independent Living for Young Adults with Intellectual Disability: A Scoping Review

Scandinavian Journal of Disability Research
Background: The transition to adulthood represents a pivotal period for young adults with intellectual disabilities. Yet limited research exists on how their lived experiences align with the right to independent living as enshrined in Article 19 of the ...
Iselin Evensen, Line Melboe, Anita Borch
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Risk factor analysis of falls in elderly patients at the geriatric and internal medicine clinics of a general hospital: A cross-sectional study

Lentera Perawat
Background: Increasing life expectancy has led to a larger elderly population vulnerable to health problems, particularly fall risk. Falls in older adults can result in injury, disability, and death, thus requiring comprehensive risk analysis ...
Riana Puspa, Nani Sari Murni, Chairil Zaman   +2 more
doaj   +1 more source

newcastle-living-lab/living-lab: Version 1.15.0

, 2019
v1.15.0 <ul> <li>Added support for <a href="https://www.npmjs.com/package/pkg">pkg</a>.</li> </ul> Pkg support <p>The Living Lab project can now be built as a standalone runtime using <code>pkg</code>.
Newcastle Living Lab, Craig A Rodway
core   +1 more source