Results 161 to 170 of about 6,147,251 (299)

Transition from Straight Lateral to Direct Anterior Approach in Hip Hemiarthroplasty: Preservation of Independent Living and Lower 1-Year Mortality. [PDF]

J Clin Med
Hees JV, Visser LCE, Groen S, Landman EBM, Bolink SAAN.   +4 more
europepmc   +1 more source

Promoting Self-Management and Independent Living of Older Individuals with Chronic Diseases through Technology: A Study of Self-Reported Needs, Priorities, and Preferences. [PDF]

Medicina (Kaunas), 2023
Kalaitzaki A, Rovithis M, Dimitropoulos A, Koukouli S, Linardakis M, Katsiri E, Rikos N, Vasilopoulos G, Tsolas G, Papachristou A, Dimitrantzou A, Katsiris D, Stavropoulou A.   +12 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The "ELDERDES" model: how older adults' adoption of digital environment solutions improves residential experiences, health outcomes, and enables independent living. [PDF]

Front Public Health
Golant SM.
europepmc   +1 more source

Assessing Older Adults' Decision-Making Capacity for Independent Living: Practice Tensions and Complexities. [PDF]

J Appl Gerontol, 2022
Usher R, Stapleton T.
europepmc   +1 more source

Developing successful employment opportunities forum for Ohioans with disabilities, August 18, 2009, Hyatt Regency Hotel, Columbus, Ohio : summary of testimony.

, 2009
Title from PDF cover (viewed on Dec. 4, 2009); Hosted by: Ohio Developmental Disabilities Council, Ohio Statewide Independent Living Council, Ohio Governor's Council on People with Disabilities.; Harvested from the web on 12/4 ...

core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Assessment of Support for Independent Living: Perspectives of People With Intellectual Disabilities and Support Professionals. [PDF]

J Appl Res Intellect Disabil
Fullana J, Pallisera M, Díaz-Garolera G.   +2 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source