Results 61 to 70 of about 1,652,945 (232)

Universal cosmological solutions in Lovelock gravity

European Physical Journal C: Particles and Fields
This paper explores the Friedmann field equations within the framework of Lovelock gravity, a natural extension of Einstein’s gravity, focusing on both flat and open universes.
A. V. Nikolaev
doaj   +1 more source

Socio-economic factors affecting agro-forestry technology adoption in Nyando, Kenya

Journal of Water and Land Development, 2018
Agro-forestry (AFR) technologies are perceived to improve livelihoods and natural resource sustainability of the rural households. Despite their aggressive promotion by multiple national and international agencies, the adoption of AFR technologies has ...
Magugu John W., Feng Song, Huang Qiuqiong, Ototo Gilbert O   +3 more
doaj   +1 more source

TeV Scale Lee-Wick Fields out of Large Extra Dimensional Gravity

, 2008
We study the gravitational corrections to the Maxwell, Dirac and Klein-Gorden theories in the large extra dimension model in which the gravitons propagate in the (4+n)-dimensional bulk, while the gauge and matter fields are confined to the four ...
B. S. DeWitt, Feng Wu, G. ’t Hooft, L. F. Abbott, Ming Zhong   +4 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Lymphocytes with Cytotoxic Activity Induce Rapid Microtubule Axonal Destabilization Independently and before Signs of Neuronal Death

ASN Neuro, 2013
MS (multiple sclerosis) is the most prevalent autoimmune disease of the CNS (central nervous system) historically characterized as an inflammatory and demyelinating disease.
Nichole M. Miller, Leah P. Shriver, Vijaya L. Bodiga, Avijit Ray, Sreemanti Basu, Rajiv Ahuja, Arundhati Jana, Kalipada Pahan, Bonnie N. Dittel   +8 more
doaj   +1 more source

Thermodynamic Entropy And The Accessible States of Some Simple Systems

, 2007
Comparison of the thermodynamic entropy with Boltzmann's principle shows that under conditions of constant volume the total number of arrangements in simple thermodynamic systems with temperature-independent heat capacities is TC/k.
Blackman M, David Sands, Lavenda B H, Sears F W, Sommerfeld A, Zemansky M W   +5 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Better Autologistic Regression

Frontiers in Applied Mathematics and Statistics, 2017
Autologistic regression is an important probability model for dichotomous random variables observed along with covariate information. It has been used in various fields for analyzing binary data possessing spatial or network structure.
Mark A. Wolters
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Second gradient thermoelasticity with microtemperatures

Electronic Research Archive
This research was concerned with a linear theory of thermoelasticity with microtemperatures where the second thermal displacement gradient and the second gradient of microtemperatures are included in the classical set of independent constitutive ...
Dorin Ieşan, Ramón Quintanilla
doaj   +1 more source