Results 251 to 260 of about 983,866 (300)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A radio-pathological fusion model for predicting PD-L1 expression and immunotherapy response in non-small cell lung cancer. [PDF]

Insights Imaging
Huang D, Xu F, Gan Y, Ding L, Lou K, Li Y, Xie D, Zhang H, Shi L, Xu R, Hu H.   +10 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Interpretable LightGBM model for predicting postoperative gastrointestinal hemorrhage in elderly hip fracture patients: leveraging systemic inflammation and medication exposures for personalized risk stratification. [PDF]

BMC Geriatr
Sai H, Ren J, Ma X, Yang K, Bai C, Liu M, Zhao F, Chen H, Li X.   +8 more
europepmc   +1 more source

Conventional MRI-Based Semantic Features for Differentiation of Pediatric Medulloblastoma and Ependymoma in the Fourth Ventricle: Insights From a Multi-Center Retrospective Study. [PDF]

CNS Neurosci Ther
Han Y, Wang YY, Hao YW, Xi YB, Qi YH, Du XL, Cui WJ, Xiu SJ, Zhou XY, Wang W, Li WC, Zhang J.   +11 more
europepmc   +1 more source

Automatic early detection of pathological signs following primary total hip arthroplasty using radiographs, clinical scores, and comorbidities. [PDF]

PLoS One
Galante S, Corti A, Stuani R, Chiappetta K, Loppini M, Corino VDA.   +5 more
europepmc   +1 more source

iDeepLC: Chemical Structure Information Yields Improved Retention Time Prediction of Peptides with Unseen Modifications. [PDF]

Anal Chem
Nameni A, Declercq A, Gabriels R, Devreese R, Degroeve S, De Maesschalck A, Dhaenens M, Chiva C, Sabidó E, Martens L, Bouwmeester R.   +10 more
europepmc   +1 more source

HCCaging: a liver physiological aging-related biomarker for hepatocellular carcinoma diagnosis based on transcriptome data. [PDF]

NPJ Aging
Yu B, Zhang Y, Tang Y, Hu M, Wei J.
europepmc   +1 more source