Results 81 to 90 of about 4,267,953 (306)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Minimal Distortion Principle versus Back Projection for Independent Vector Analysis

ENP Engineering Science Journal
This short communication deals with the scaling ambiguity issue in blind convolutive source separation when performed in the frequency domain. It discusses the relationship between two major techniques, mainly the Minimal Distortion Principle and the ...
Soufiane Tebache, Adel Belouchrani, Lynda Berrah, Nacira Mendjel   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Auxiliary function-based algorithm for blind extraction of a moving speaker

EURASIP Journal on Audio, Speech, and Music Processing, 2022
In this paper, we propose a novel algorithm for blind source extraction (BSE) of a moving acoustic source recorded by multiple microphones. The algorithm is based on independent vector extraction (IVE) where the contrast function is optimized using the ...
Jakub Janský, Zbyněk Koldovský, Jiří Málek, Tomáš Kounovský, Jaroslav Čmejla   +4 more
doaj   +1 more source

Results on lattice vector quantization with dithering [PDF]

, 1996
The statistical properties of the error in uniform scalar quantization have been analyzed by a number of authors in the past, and is a well-understood topic today. The analysis has also been extended to the case of dithered quantizers, and the advantages
Kiraç, Ahmet, Vaidyanathan, P. P.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

From Informed Independent Vector Extraction to Hybrid Architectures for Target Source Extraction

IEEE Open Journal of Signal Processing
This article revises informed independent vector extraction (iIVE) as a framework for connecting model-based blind source extraction (BSE) with deep learning. We introduce the contrast function for iIVE, which is derived by extending IVE with beamforming-
Zbynek Koldovsky, Jiri Malek, Martin Vratny, Tereza Vrbova, Jaroslav Cmejla, Stephen O'Regan   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Nab Experiment: A Precision Measurement of Unpolarized Neutron Beta Decay [PDF]

, 2019
Neutron beta decay is one of the most fundamental processes in nuclear physics and provides sensitive means to uncover the details of the weak interaction.
Fry, J., Alarcon, R., Baessler, S., Balascuta, S., Barron-Palos, L., Bailey, T., Bass, K., Birge, N., Blose, A., Borissenko, D., Bowman, J. D., Broussard, L. J., Bryant, A. T., Byrne, J., Calarco, J. R., Caylor, J., Chang, K., Chupp, T., Cianciolo, T. V., Crawford, C., Ding, X., Doyle, M., Fan, W., Farrar, W., Fomin, N., Frlez, E., Gericke, M. T., Gervais, M., Gluck, F., Greene, G. L., Grzywacz, R. K., Gudkov, V., Hamblen, J., Hayes, C., Hendrus, C., Ito, T., Jezghani, A., Li, H., Makela, M., Macsai, N., Mammei, J., Mammei, R., Martinez, M., Mathews, D. G., McCrea, M., McGaughey, P., McLaughlin, C. D., Mueller, P., van Petten, D., Penttila, S. I., Perryman, D. E., Picker, R., Pierce, J., Pocanic, D., Qian, Y., Ramsey, J., Randall, G., Riley, G., Rykaczewski, K. P., Salas-Bacci, A., Samiei, S., Scott, E. M., Shelton, T., Sjue, S. K., Smith, A., Smith, E., Stevens, E., Wexler, J., Whitehead, R., Wilburn, W. S., Young, A., Zeck, B.   +71 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source