Results 41 to 50 of about 4,259 (92)

Phosphoenolpyruvate carboxykinase 2 activation of the AMPK–CEBPB axis to enhance glutamine utilization to promote glycolysis and malignant behavior in adenocarcinomas cells under glucose deprivation

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Glucose deprivation is a key characteristic of the tumor microenvironment. In this study, we verified through in vitro experiments that phosphoenolpyruvate carboxykinase 2 (PCK2) upregulates solute carrier family 38 member 2 (SLC38A2) via the AMPK–CEBPB axis, thereby enhancing glutamine utilization in A549 cells, which in turn promotes glycolysis and ...
Libo Ruan, Kewang Xu, Wenjun Zeng, Ling Xiao, Minjun Zhao, Haiyan Zhang   +5 more
wiley   +1 more source

Using Quadratic Programming to Reconstruct Data From Published Survival and Competing Risks Analyses

Statistics in Medicine, Volume 45, Issue 6-7, March 2026.
ABSTRACT The ability to retrieve pseudo‐individual patient data (IPD) from published survival study results is important to facilitate meta‐analysis, evidence synthesis or secondary data analyses for the purpose of decision modeling for cost effectiveness analysis. While established methods exist for retrieving pseudo‐IPD from Kaplan–Meier plots, these
Andrew C. Titman
wiley   +1 more source

Linking Cortical Morphometry in Self‐Limited Epilepsy With Centrotemporal Spikes to Cognition, Function, and Molecular Architecture

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
This study provides a novel framework modeling neurodevelopment in self‐limited epilepsy with centrotemporal spikes. We identify eight biologically interpretable brain structural deviation patterns, which are linked to clinical phenotypes and molecular profiles involving cognition and mitochondrial function. This integration elucidates multidimensional
Siqi Yang, Jie Xia, Wei Liao, Yimin Zhou, Chengzong Peng, Juan Wang, Zhiqiang Zhang   +6 more
wiley   +1 more source

Targeting MGAT4A‐Mediated N‐Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion

Exploration, Volume 6, Issue 1, February 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive type of primary brain tumor, and its invasive properties contribute significantly to incomplete surgical resection and tumor recurrence. Despite extensive clinical efforts to mitigate GBM invasion, targeted therapies against GBM stem cells (GSCs), which drive invasion, remain incompletely understood ...
Rui Niu, Meichen Liu, Qingshan Yang, Jinlong Yin   +3 more
wiley   +1 more source

Evolutionary taxonomy and conservation status of environmentally sensitive and endangered musk deer (Moschus spp.): An updated review

Conservation Science and Practice, Volume 8, Issue 2, February 2026.
This study reviews the historical taxonomic classification and evolutionary background of musk deer, clarifying long‐standing confusion in their identification. It highlights the current global distribution and conservation status of these species, emphasizing the threat posed by poaching and habitat destruction. The work aims to raise public awareness
Zhirong Zhang, Yun Su, Wenbin Yan, Zongzhi Li, Tianhua Hu, Jiwu Zhang, Liwei Teng, Zhensheng Liu   +7 more
wiley   +1 more source

Resting-state fMRI dynamic functional network in young children with Tourette syndrome

Frontiers in Neurology
IntroductionTourette syndrome (TS) is a neurodevelopmental disorder characterized by involuntary motor and phonic tics, with diagnosis often delayed due to the 1-year symptom duration criterion.
Haode Wang, Yue Liu, Yue Liu, Chen Zhang, Jingtao Lian, Lei Yang, Yun Peng   +6 more
doaj   +1 more source

Additively Manufacturable High‐Strength Aluminum Alloys with Coarsening‐Resistant Microstructures Achieved via Rapid Solidification

Advanced Materials, Volume 38, Issue 4, 16 January 2026.
Rapid solidification in laser additive manufacturing facilitates the precipitation of metastable phases in aluminum alloys. These metastable phases significantly enhance the strength by forming a high‐volume fraction of precipitates with an order of magnitude reduced sizes and smaller interspacing, effectively impeding dislocation motion. Consequestly,
S. Mohadeseh Taheri‐Mousavi, Michael Xu, Florian Hengsbach, Clay Houser, Zhaoxuan Ge, Benjamin Glaser, Shaolou Wei, Mirko Schaper, James M. LeBeau, Greg B. Olson, A. John Hart   +10 more
wiley   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

Collagen Type II-Targeting Lentiviral Gene Therapy for Mucopolysaccharidosis IVA. [PDF]

Curr Issues Mol Biol
Celik B, Saikia S, Khan S, Musini KS, Tomatsu S.   +4 more
europepmc   +1 more source

A Dimensionality Reduction Approach for Motor Imagery Brain-Computer Interface Using Functional Clustering and Graph Signal Processing. [PDF]

J Med Signals Sens
Khalili MD, Abootalebi V, Saeedi-Sourck H.   +2 more
europepmc   +1 more source