Results 61 to 70 of about 211 (100)

YAP‐activated lymph node fibroblasts contribute to extracellular matrix remodeling associated with extranodal extension of oral squamous cell carcinoma

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Desmoplasia, characterized by excessive expansion of cancer‐associated fibroblasts (CAFs) and aberrant extracellular matrix (ECM) deposition, is widely present especially in invasive cancers. The extranodal extension (ENE) of nodal metastasis involves the extension of invasive tumor cells through the lymph node capsule into the perinodal ...
Qian Zhang, Shanben Jiang, Ansardin Abliz, Sheng Chen, Qingang Hu, Liang Ding, Yuxin Wang   +6 more
wiley   +1 more source

GATA3 Inhibits the Expression of Viral E6/E7 Genes, and Its Expression Is Compromised During HPV‐Mediated Cervical Carcinogenesis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT High‐risk human papillomaviruses (HPV) are the main etiological agents of cervical cancer. The viral early promoter regulates the expression of E6/E7 oncoproteins, and its transcriptional activity is positively or negatively regulated by host transcription factors (TFs) that are able to bind to the viral long control region (LCR).
Valéria Talpe‐Nunes, Aline Lopes Ribeiro, Rafaella Almeida Nunes, João Simão Sobrinho, Amanda Schiersner Caodaglio, Rossana Veronica Mendonza Lopez, Thais Rocha, Maria Luiza Nogueira Dias Genta, Konstanze Schichl, Ademola Aiyenuro, John Doorbar, Laura Sichero   +11 more
wiley   +1 more source

Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang, Yiqiong Song, Ziyang Wang, Ke Chao, Lifeng Li, Xu Zhang, Xiaoran Duan, Chenglong Yu, Ruyue Xue, Jie Zhao   +9 more
wiley   +1 more source

Concurrent Chemoradiotherapy Plus Immunotherapy Versus Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer: A Randomized, Single‐Center, Phase II Trial of Early Tumor Regression and Pro‐Inflammatory Tumor Microenvironment Remodeling

MedComm, Volume 7, Issue 7, July 2026.
Concurrent chemoradiotherapy plus immunotherapy (CICRT) promotes tumor microenvironment remodeling in locally advanced cervical cancer to enhance antitumor immunity. It reduces regulatory T cells and mitigates CD8+ T‐cell exhaustion while reprogramming macrophages toward a pro‐inflammatory phenotype. Furthermore, CICRT upregulates MHC‐II expression and
Yuhan Sheng, Yu Chang, Yao Jiang, Shujie Wang, Ying Zhou, Minggang Peng, Xiang Kang, Yingchao Zhao   +7 more
wiley   +1 more source

Resting-state fMRI dynamic functional network in young children with Tourette syndrome

Frontiers in Neurology
IntroductionTourette syndrome (TS) is a neurodevelopmental disorder characterized by involuntary motor and phonic tics, with diagnosis often delayed due to the 1-year symptom duration criterion.
Haode Wang, Yue Liu, Yue Liu, Chen Zhang, Jingtao Lian, Lei Yang, Yun Peng   +6 more
doaj   +1 more source

Aging and Hearing with Vestibular Schwannoma Beyond Presbycusis: A Large Cross‐Sectional Audiometric and Volumetric Study

OTO Open, Volume 10, Issue 3, July-September 2026.
Abstract Objective To identify predictors of auditory function in treatment‐naïve vestibular schwannomas (VS) while accounting for age‐related hearing loss, investigating baseline volumetrics and audiometrics in a pre‐intervention stereotactic radiosurgery (SRS) cohort. Study Design Cross‐sectional study.
Sami Barrit, Mejdeddine Al Barajraji, Salim El Hadwe, Jérome R. Lechien, Daniele Morelli, Cécile Renier, Nicolas Massager   +6 more
wiley   +1 more source

Unlocking Nanoscale Microstructural Detail in Aluminum Alloys Through Differential Phase Contrast Segmentation in STEM

Small Methods, Volume 10, Issue 13, 8 July 2026.
Differential phase contrast (DPC) imaging in STEM is demonstrated as a rapid, versatile segmentation tool for advanced aluminum alloys. Decomposition of false‐color DPC micrographs resolves nanoclusters, precipitate variants, dislocation strain fields, nanostructures, and grain boundaries ‐ all within a single and fast acquisition.
Matheus A. Tunes, Martin Hasenburger, Rostislav Daniel, Oscar M. Prada‐Ramirez, Philip Aster, Sebastian Samberger, Thomas M. Kremmer, Johannes A. Österreicher   +7 more
wiley   +1 more source

Adaptive Constrained Independent Vector Analysis: Application to Large-Scale fMRI Analysis [PDF]

, 2020
Functional magnetic resonance imaging (fMRI) provides non-invasive indirect measures of neuronal activation in the brain. Analysis of large-scale fMRI datasets, acquired from a large pool of individuals, has become prominent in recent studies for the ...
Bhinge, Suchita
core   +1 more source

Inverse-free Online Independent Vector Analysis with Flexible Iterative Source Steering [PDF]

, 2022
In this paper, we propose a new online independent vector analysis (IVA) algorithm for real-time blind source separation (BSS). In many BSS algorithms, the iterative projection (IP) has been used for updating the demixing matrix, a parameter to be ...
Ono, Nobutaka, Nakashima, Taishi
core   +1 more source

Source extraction using informed independent vector analysis [PDF]

, 2018
LAUREA MAGISTRALELa separazione alla cieca di sorgenti audio mira a estrarre un certo numero di segnali sorgente da un insieme di segnali di osservazione; il termine "alla cieca" è utilizzato perché nessuna (o poca) informazione a riguardo delle ...
ARANGO, LUIS GERMAIN
core