Results 161 to 170 of about 13,067,159 (317)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Quantification of Removable Prosthesis Plaque Area Coverage Among Adult Patients: A Systematic Review and Meta-Analysis. [PDF]

Clin Exp Dent Res
Lim TW, Abuzaid MM, Wong JYK, Li KY, Burrow MF, McGrath C.   +5 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Index Index [PDF]

Index on Censorship, 1987
openaire   +2 more sources

Index [PDF]

, 1936

core   +4 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Index index [PDF]

Index on Censorship, 1978
openaire   +2 more sources

Triglyceride-glucose index as a potential evaluation tool for all-cause mortality in ischemic stroke patients undergoing endovascular therapy: a multicenter cohort study. [PDF]

BMC Endocr Disord
Sun Y, Zhu X, Han J, Deng W.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Effect of a digital training package on clinical outcomes in Malawi's index case testing programme: a cluster randomised controlled trial. [PDF]

BMJ Glob Health
Rosenberg N, Mollan K, Wang J, Tembo T, Chitani M, Wetzel E, Rutstein SE, Mwapasa V, Phiri D, Mkandawire A, Go V, Kim M, Ahmed S, Simon KR.   +13 more
europepmc   +1 more source