Results 201 to 210 of about 12,950,772 (293)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Prognostic and functional value of left atrial indices in advanced heart failure. [PDF]

Cardiovasc Ultrasound
Karaçam M, Kültürsay B, Kaya A, Tanyeri S, Mutlu D, Efe SÇ, Bulus Ç, Halil GS, Eminoğlu H, Kırali K, Acar RD.   +10 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Ecological Effects of <i>Solanum rostratum</i> Invasion on the Diversity and Functional Traits of Native Plant Communities. [PDF]

Ecol Evol
Hu L, Jiang L, Qiu J, Yimingniyazi A.
europepmc   +1 more source

Validation of the Hematopoietic Cell Transplantation–Specific Comorbidity Index in Nonmyeloablative Allogeneic Stem Cell Transplantation

, 2017
Muthu Veeraputhiran, Lingyao Yang, Vandana Sundaram, Sally Arai, Robert Lowsky, David B. Miklos, Everett Meyer, Lori Muffly, Robert S. Negrin, Andrew R. Rezvani, Judith A. Shizuru, Wen Kai Weng, Laura Johnston   +12 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Associations Between the Cardiovascular Health Diet Index (CHDI) and Cardiometabolic Risk Factors in Brazilian Workers: A Cross-Sectional Study. [PDF]

J Hum Nutr Diet
Araujo EMS, Hayashi D, de Assumpção D, Andrechuk CRS, Pagamicce LT, Neves MLDS, Rodrigues RCM, Cornélio ME.   +7 more
europepmc   +1 more source

The relationship between body mass index and mental disorders in the adult population

, 2020
А.В. Голенков, I. V. Madyanov, Shmeleva SV, Galina D. Petrova, Н Н Камынина, Nikita V. Logachov   +5 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Consumption of Selected Healthy and Unhealthy Food Groups and Associations With Nutritional Status Among Children 2-5 Years of Age in Northern Ghana. [PDF]

Matern Child Nutr
Becher ER, Kumordzie SM, Davis JN, Arnold CD, Ryan Wessells K, Tan X, Fuseini AD, Adams KP, Haskell MJ, Vosti SA, Adu-Afarwuah S, Engle-Stone R.   +11 more
europepmc   +1 more source