Results 91 to 100 of about 199,214 (291)
پیاورد سلامت, 2017 Background and Aim: In the recent years the number of science research health journals has increased in Iran. These journals should be based on the standards and criteria required in international indexing database. The aim of this study was to determine
Azam Shahbodaghi +3 more
doaj
Are letters to the Editor Published in the Journal of Alzheimer’s Disease Undervalued? [PDF]
Neurology LettersLetters to the editor (LTEs) play small, but sometimes important, functions, in biomedicine, including the neurosciences. Journal of Alzheimer’s Disease (JAD), a prominent and solidly ranked (Q2 on SJR, #43) journal dedicated exclusively to this ...
Jaime A. Teixeira da Silva
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Effective retrieval and new indexing method for case based reasoning: Application in chemical process design [PDF]
, 2010 In this paper we try to improve the retrieval step for case based reasoning for preliminary design. This improvement deals with three major parts of our CBR system.
Le Lann, Jean-Marc +2 more
core +1 more source
Revisiting Indexing & Abstracting in the Digital Era [PDF]
, 2018 Paper presented for the 2018 Multidisciplinary Information Research Symposium. This paper discusses emerging trends for digital libraries and argues that indexing and abstracting services are still on the path to rediscovering and effectively accessing ...
O'Bryant, Kathleen +8 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source