Results 121 to 130 of about 119,163 (257)

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Migrant Integration Policy Index.

, 2007
info:eu-repo/semantics ...
Niessen, Jan, Huddleston, Tom, Citron, Laura, Geddes, Andrew, Jacobs, Dirk   +4 more
openaire   +1 more source

What can America learn from the British tax system? [PDF]

This paper examines elements of British tax policy and discusses their implications for the US, where several recent proposals would mirror aspects of the British system.
William Gale
core  

Chapter 2 - A Discussion of Methods, pp. 31-44 [PDF]

, 1944
The Catherwood Library and ILR School at Cornell are pleased to again make available an extremely important index of major labor union publications, long out of print. It is Lloyd G. Reynolds and Charles C.
Killingsworth, Charles C, Reynolds, Lloyd G   +1 more
core   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Real Dollarization, Financial Dollarization, and Monetary Policy [PDF]

This paper explores the interaction of real dollarization (dollar indexing of wages), financial dollarization (dollar denomination of financial contracts) and monetary policy in a general equilibrium model with real shocks.
Alain Ize, Eric Parrado
core  

Promotion to MEDLINE, indexing with Medical Subject Headings, and open data policy for the [PDF]

Journal of Educational Evaluation for Health Professions, 2016
Sun Huh
doaj   +1 more source

All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery

Advanced Science, EarlyView.
Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi, Brooke E. Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y. Ma, Chinmay S. Potnis, Soumen Saha, Xinghai Li, Max R. Ney, Sarah Y. Kim, Joshua J. Milligan, Lixin Fan, Matthew L. Becker, Daniel Reker, Ashutosh Chilkoti   +15 more
wiley   +1 more source

Special Libraries, February 1951 [PDF]

, 1951
Volume 42, Issue 2https://scholarworks.sjsu.edu/sla_sl_1951/1001/thumbnail ...
Special Libraries Association
core   +2 more sources

Integrating an AI Copilot into a Knowledge Management System for Civil Protection: A Development-Oriented Case Study from Romania [PDF]

Ovidius University Annals: Economic Sciences Series
This paper presents the conceptual framework and ongoing development of a local AI Copilot system designed to support knowledge management and decision-making within the Romanian civil protection authority.
Alexandru Ioan
doaj