Results 141 to 150 of about 181,723 (258)

Optimal subsampling for regression with mixed‐type predictors

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Subsampling has emerged as an appealing strategy to mitigate the computational and storage challenges imposed by large datasets. Recent subsampling techniques have shown notable computational gains for data dominated by numerical predictors. However, real‐world datasets frequently contain both numerical and categorical predictors.
Jiaqing Zhu, Lin Wang, Fasheng Sun
wiley   +1 more source

Author Correction: Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease. [PDF]

open access: yesNat Commun
Xu J   +14 more
europepmc   +1 more source

Arabidopsis AUGMIN8 Contains Two Independent Microtubule Association Domains

open access: yesCytoskeleton, EarlyView.
ABSTRACT Plant cells create a plasma membrane‐associated network of microtubules that are nucleated by γ‐tubulin ring complexes primarily through microtubule‐dependent microtubule nucleation (MDMN). This dynamic array organizes into specific patterns in response to developmental and environmental cues to influence primary cell wall construction.
Naveen K. Chana   +2 more
wiley   +1 more source

Microtubule Destabilizing Kinesins: A Historical Perspective and Thoughts for the Future

open access: yesCytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton plays critical roles in multiple cellular processes such as mitotic spindle assembly and chromosome segregation. Cells contain a number of microtubule‐associated proteins that regulate microtubule dynamics both temporally and spatially in cells. The microtubule depolymerizing kinesins include members of the Kinesin‐
Claire E. Walczak
wiley   +1 more source

Transradial Access for Radial-to-Peripheral Revascularization in Acute Limb Ischemia. [PDF]

open access: yesJACC Case Rep
Halabi S   +4 more
europepmc   +1 more source

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug–Drug Interactions for Orforglipron, a Small Molecule Glucagon‐Like Peptide‐1 Receptor Agonist

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse   +7 more
wiley   +1 more source

Intelligent Automation Improved Efficiency in Pharmacovigilance Safety Signal Assessment

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pharmacovigilance is the science involving the detection, assessment, understanding, and prevention of adverse events associated with drugs, biologics, or medical devices. In pharmacovigilance, information that suggests a new potential causal relationship between an intervention and an adverse event is called a safety signal. Following their detection,
Jeffrey Warner   +3 more
wiley   +1 more source

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