Results 141 to 150 of about 1,912,742 (310)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
CAESARIAN SECTIONS: FREQUENCY AND INDICATIONS AT PERIPHERAL TERTIARY CARE HOSPITAL
Pakistan Armed Forces Medical Journal, 2018 Objective: This study was conducted to determine the frequency and indications of caesarian section (CS) at Combined Military Hospital (CMH) Abbottabad. Study Design: Descriptive cross sectional study.
Naila Tahir +3 more
doaj
Wilson-loop correlators on the lattice and asymptotic behaviour of hadronic total cross sections
, 2013 We show how universal, Froissart-like hadronic total cross sections can be obtained in QCD in the functional-integral approach to soft high-energy scattering, and we discuss indications of this behaviour obtained from lattice simulations.Comment ...
Giordano, Matteo +2 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
NA49 and NA61/SHINE experiments: results and perspectives
, 2009 The Super Proton Synchrotron (SPS) covers one of the most interesting regions of the QCD phase diagram $(T - \mu_B)$. On the one hand there are indications that the energy threshold for deconfinement is reached already at low SPS energies.
Grebieszkow, Katarzyna
core
, 2016 The aim of the essay is to survey the main issues raised by global indicators, and to critically review the state of the art of the field’s literature. For this purpose, the chapter begins by defining global indicators and by placing their historical rise in the wider cultural context of the increasing power of quantitative knowledge over the past two ...
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source