Results 151 to 160 of about 1,912,742 (310)

Finding the most promising indications for novel treatments in oncology. [PDF]

NPJ Precis Oncol
Eckhoff M, Klingelschmitt S, Van Ruijssevelt L, Grossmann S, Zichner T, Stümpges P, Roschewitz D, Mlecnik B, Merger M, Graen P, Kumar J, Devereson A, Wurzer S, Bleys J, Albrecht B, Hach D, Haslinger C.   +16 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Pediatric Tracheostomy: A Five-year Retrospective Review at a Tertiary Care Center. [PDF]

Turk Arch Otorhinolaryngol
Fathima A, P PK, Raju S.
europepmc   +1 more source

Assessing the use of Geographical Indications for the New England wine region in NSW [PDF]

Geographical Indications (GIs) have increasingly been used as a marketing tool to create an image of quality and uniqueness, and so capture premium prices.
Campbell, Gene, Chang, Hui-Shung (Christie), Sniekers, Peter   +2 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Appropriateness of Indications and Factors Associated With Abnormal Findings in Upper Gastrointestinal Endoscopy at the National Referral Hospital, Bhutan: A Cross-Sectional Study. [PDF]

Health Sci Rep
Gawa T, Dorjey Y, Dargay S.
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Indications and socio-demographic determinants of blood transfusion among children attending secondary health facilities in South-East Nigeria

Nigerian Journal of Paediatrics
Background: The complications associated with blood transfusion can be reduced by carefully preventing the conditions necessitating transfusion especially the common ones.
Ezenwosu OU, Udorah MI, Udechukwu NP, Ibe Bede C   +3 more
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Are We Heading into a Dead End, or Are We Treading Water? [PDF]

Toxins (Basel)
Jost WH.
europepmc   +1 more source