Results 121 to 130 of about 822 (259)

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

open access: yesAdvanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu   +5 more
wiley   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

open access: yesAdvanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia   +4 more
wiley   +1 more source

How children and adults keep track of real information when thinking counterfactually. [PDF]

open access: yesPLoS One, 2020
Gómez-Sánchez J   +2 more
europepmc   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

open access: yesAdvanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie   +12 more
wiley   +1 more source

Paul Grice on Indicative Conditionals

open access: yes
Grice argues that indicative conditionals ‘if p then q’ have conventional, truth conditional meaning according to the material conditional ‘p q’. In order to explain away the known paradoxes with this interpretation, he distinguishes between truth ...
Anjum, Rani Lill
core  

Indicative Conditionals are Material - Expanding the Survey [PDF]

open access: yes
Adam Rieger (2013) has carried out a survey of arguments in favour of the material account of indicative conditionals. These arguments involve simple and direct demonstrations of the material account.
Silva, Matheus Martins
core  

Baseline Conditions and Indicators

open access: yes
Section I Chapter 1: Baseline Conditions and Indicators Focuses on establishing current state baselines for water, food, energy, health, and climate systems. Submissions may include: Data sets quantifying resource availability, emissions, land use, or health outcomes Methodologies for indicator selection, standardization, and data integration ...
openaire   +2 more sources

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

open access: yesAdvanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang   +10 more
wiley   +1 more source

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