Results 31 to 40 of about 177,671 (276)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Goal-directed therapy in intraoperative fluid and hemodynamic management. [PDF]

open access: yes, 2013
Intraoperative fluid management is pivotal to the outcome and success of surgery, especially in high-risk procedures. Empirical formula and invasive static monitoring have been traditionally used to guide intraoperative fluid management and assess volume
Gutierrez, Maria Cristina   +2 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Cardiac output monitoring

open access: yesAnnals of Cardiac Anaesthesia, 2008
Minimally invasive and non-invasive methods of estimation of cardiac output (CO) were developed to overcome the limitations of invasive nature of pulmonary artery catheterization (PAC) and direct Fick method used for the measurement of stroke volume (SV).
Mathews Lailu, Singh Kalyan
doaj  

Formation of plaques in chick embryo tissue cultures by the virus of herpes simplex [PDF]

open access: yes, 1954
Thesis (M.A.)--Boston UniversityStudies on the virus of herpes simplex have been done in t he past by using t he embryonated egg and the newborn mouse.
Bergs, Visvaldis Viktors
core   +1 more source

Current methods for characterising mixing and flow in microchannels [PDF]

open access: yes, 2010
This article reviews existing methods for the characterisation of mixing and flow in microchannels, micromixers and microreactors. In particular, it analyses the current experimental techniques and methods available for characterising mixing and the ...
Aubin, Joelle   +2 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Surface water quality evaluation, apportionment of pollution sources and aptness testing for drinking using water quality indices and multivariate modelling in Baitarani River basin, Odisha

open access: yesHydroResearch
Baitarani River, Odisha, faces serious deterioration due to massive human intervention. It is particularly susceptible to degradation because it receives industrial and waste water emissions from surrounding organizations and municipal bodies.
Abhijeet Das
doaj   +1 more source

Evaluating the Stormwater Treatment Performance of AbTech Industries Smart Sponge® Plus, Landry, N [PDF]

open access: yes, 2004
The ability of AbTech’s Smart Sponge® Plus to remove fecal-borne bacteria from stormwater was evaluated in a storm drainage system located in Seabrook, New Hampshire.
Jones, Stephen H.   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

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