Results 31 to 40 of about 6,034,294 (262)
Aquatic vegetation is a reliable indicator of the ecological condition of surface waters. Abundance, composition and spatial structure of aquatic communities are shaped by an array of factors, which include both natural abiotic features of an ecosystem ...
Agnieszka Kolada +2 more
doaj +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Lithium-thermal double indicator dilution: a new method of extravascular lung water measurement in the critically ill? [PDF]
MD (Res)There is evidence to suggest that therapy targeted at normalising extravascular lung water volume (EVLW) can improve outcomes from critical illness.
Maddison, Ben
core +4 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Estimation of extravascular lung water by indicator-dilution techniques. [PDF]
• An abnormal increase in the volume of the extravascular fluid of the lungs can occur in cardiogenic pulmonary edema, the adult respiratory distress syndrome, and other situations such as the "shock lung" and the "wet lung." Knowledge of this volume can be important in assessing the threat to the patient and the efficacy of measures taken to alter ...
openaire +2 more sources
Simulating a Ground Truth for Transit Time Analysis of Indicator Dilution Curves [PDF]
Transit times of a bolus through an organ can provide valuable information for researchers, technicians and clinicians. Therefore, an indicator is injected and the temporal propagation is monitored at two distinct locations.
Reiß, Michael, Nahm, Werner, Naber, Ady
core +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Minimally invasive and non-invasive methods of estimation of cardiac output (CO) were developed to overcome the limitations of invasive nature of pulmonary artery catheterization (PAC) and direct Fick method used for the measurement of stroke volume (SV).
Mathews Lailu, Singh Kalyan
doaj
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source

