Results 101 to 110 of about 46,142 (281)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries

Communications Chemistry
The large-scale analysis of small-molecule binding to diverse RNA structures is key to understanding the required interaction properties and selectivity for developing RNA-binding molecules toward RNA-targeted therapies.
Ryosuke Nagasawa, Kazumitsu Onizuka, Kaoru R. Komatsu, Emi Miyashita, Hirotaka Murase, Kanna Ojima, Shunya Ishikawa, Mamiko Ozawa, Hirohide Saito, Fumi Nagatsugi   +9 more
doaj   +1 more source

A Diboronic Acid-Based Fluorescent Sensor Array for Rapid Identification of Lonicerae Japonicae Flos and Lonicerae Flos

Molecules
Lonicerae japonicae flos (LJF) and Lonicerae flos (LF) are traditional Chinese herbs that are commonly used and widely known for their medicinal properties and edibility.
Ying Bian, Chenqing Xiang, Yi Xu, Rongping Zhu, Shuanglin Qin, Zhijun Zhang   +5 more
doaj   +1 more source

Metallothionein as an indicator of water quality: assessment of the bioavailability of cadmium, copper, mercury and zinc in aquatic animals at the cellular level [PDF]

, 1994
The study of metallothioneins (MTs) has greatly improved our understanding of body burdens, metal storage and detoxification in aquatic organisms subjected to contamination by the toxic heavy metals, Cd, Cu, Hg and Zn.
George, S.G., Langston, W.J.
core  

Variation in plasma oxidative status and testosterone level in relation to egg-eviction effort and age of brood-parasitic common cuckoo nestlings [PDF]

, 2012
To avoid competition for parental care, brood-parasitic Common Cuckoo (Cuculus canorus) nestlings evict all of the host's eggs and nestlings within a few days after hatching.
CavalleRi, CgRaw, CkMan, Cli RD, CoHen, CoHen, CoRaglio, Costantini D., Costantini D., Csaba Moskát, David Costantini, Davies, Davies, Del Rio D., Dietz M., Din D., Dkins-Regan, DsHi P, Felt RD, Halliwell, Hanan, Hanan, Hantz, HaRt, Haube R, HelFenstein F., HollMén, Honza M., Jaime Muriel, Janaszewska, Ji, leCk C. M., Ma M., Mark E. Hauber, MaRtín D., MetCalFe, Miklós Bán, Molná R, MonagHan P., Moskát C., QuillFelDt P., Ra J. C., Ra J. C., Rai P. F., Ri M, Ri M, RigHt P. a., Rio R, Rita Hargitai, RkHea D, RootHuis, ézina F.   +51 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Chemical Research Odyssey: From High School Foundations to University Frontiers

CHIMIA
Practicing research in high school is essential for preparing future university students, fostering critical thinking, and situating scientific knowledge within a broader context. However, such training remains rare in upper secondary education. Over the
Thibaud Rossel
doaj   +1 more source

Automated biowaste sampling system urine subsystem operating model, part 1 [PDF]

The urine subsystem automatically provides for the collection, volume sensing, and sampling of urine from six subjects during space flight. Verification of the subsystem design was a primary objective of the current effort which was accomplished thru the
Fogal, G. L., Mangialardi, J. K., Rosen, F.   +2 more
core   +1 more source

Index to 1981 NASA Tech Briefs, volume 6, numbers 1-4 [PDF]

, 1986
Short announcements of new technology derived from the R&D activities of NASA are presented. These briefs emphasize information considered likely to be transferrable across industrial, regional, or disciplinary lines and are issued to encourage ...

core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source