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Fluorescent Indicator Displacement Assay for Ligand−RNA Interactions
Journal of the American Chemical Society, 2010Since the discovery of the RNA functions modulating gene expression, functional RNA has become an attractive drug target. Ligand-RNA interactions have been studied by covalent labeling of either the ligand or RNA with fluorescent dyes or immobilization on the sensing devices. However, it is desirable to investigate the interactions without any chemical
Jinhua, Zhang +2 more
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Indicator displacement assay for freshness monitoring of green tea during storage
Food Research International, 2023Aging of green tea leads to reductions in its flavor and health value, yet in situ testing methods for green tea freshness are lacking. A novel sensitive indicator displacement assay (IDA) sensor was constructed and applied for monitoring of green tea freshness during storage.
Yiyi, Zhang +4 more
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Carbohydrate sensing with a metal-based indicator displacement assay
Chemical Communications, 2011A Pd-based indicator displacement assay for the fluorimetric sensing of carbohydrates has been developed. The assay allows the detection of saccharides in the low millimolar concentration range in water at neutral pH.
Vera, Janowski, Kay, Severin
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Allosteric Indicator Displacement Enzyme Assay for a Cyanogenic Glycoside
Chemistry – A European Journal, 2013AbstractIndicator displacement assays (IDAs) represent an elegant approach in supramolecular analytical chemistry. Herein, we report a chemical biosensor for the selective detection of the cyanogenic glycoside amygdalin in aqueous solution. The hybrid sensor consists of the enzyme β‐glucosidase and a boronic acid appended viologen together with a ...
Jose, D. Amilan +2 more
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An indicator displacement assay recognizes enantiomers of chiral carboxylates
Chemical Communications, 2019Analyte chirality induces changes in fluorescence.
Sara Sheykhi +3 more
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Molecular recognition and indicator-displacement assays for phosphoesters
Tetrahedron, 2004Abstract The binding affinities of host 1 towards different phosphoesters were studied. An indicator-displacement assay was also performed, which was able to detect the host–guest interactions with a small visual color change. The degree of substitutions of the phosphate, the functionality of the substituents, and the steric bulk of the ...
Tianzhi Zhang, Eric V. Anslyn
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Cucurbituril-mediated AIE: An unconventional indicator displacement assay for ketamine detection
Dyes and Pigments, 2022Abstract Typical AIE luminogens with extensive π-electron conjugation are limited in use on account of their complex synthesis, high cost and environmental concerns. To this end, we report here a novel host-guest inclusion complex that is assembled from nonemissive ligands, and surprisingly exhibits notable AIE features in aqueous solution while ...
Kun Yan +8 more
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Fluorescent indicator displacement assay of ligands targeting 10 microRNA precursors
Bioorganic & Medicinal Chemistry, 2013Fluorescent indicator displacement (FID) assay is a rapid and convenient assay for identifying new ligands that bind to the target molecules. In our previous studies, we have shown that a series of 2,7-diaminoalkoxy xanthone and thioxanthone derivatives can be used as fluorescent indicators for detecting the interaction between RNA and a ligand.
Asako, Murata +3 more
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Colorimetric enantiodiscrimination of mandelic acid by indicator displacement assay
Chinese Chemical Letters, 2015Abstract The colorimetric enantiodiscrimination between mandelic acid and l -proline-Cu (II) is exploited to develop enantioselective indicator displacement assays. The sensitivity of the assay could be tuned by using a colorimetric indicator. The chromophoric ligand, pyrocatechol violet, effectively competes with the mandelic acid guest for open ...
Xue-Xian Chen, Li-Ming Yuan
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A new strategy for calibrating indicator displacement assay (IDA)-based sensor systems
Analytica Chimica Acta, 2020A novel strategy for calibrating Indicator Displacement Assay (IDA)-based sensors is presented herein. The main idea is to replace the instrumental measurement responses by the equilibrium concentration of spectroscopically active species which can be obtained by the Classical Least Squares (CLS) method. Also, coupling the Indirect Hard Modelling (IHM)
Somaiyeh Khodadadi, Karimvand +1 more
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