Results 101 to 110 of about 1,225,552 (316)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Adapting the Material Circularity Indicator to evaluate circularity in food systems: two case studies on livestock rearing

Environmental and Sustainability Indicators
In light of the growing interest in circular bioeconomy issues, this study aims to present an adaptation of the Material Circularity Indicator (MCI) for the quantitative assessment of circularity in agri-food systems. Specifically, the adapted MCI (a-MCI)
Francesco Caraceni, Matteo Cordara, Carlo Brondi, Andrea Ballarino   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A real-time recession indicator for the Euro area

In this paper, we propose a new coincident monthly indicator to detect in real-time the start and the end of an economic recession phase for the Euro area.
Ferrara, Laurent
core  

Locally Ideal Formulations for Piecewise Linear Functions with Indicator Variables

, 2013
In this paper, we consider mixed integer linear programming (MIP) formulations for piecewise linear functions (PLFs) that are evaluated when an indicator variable is turned on.
Linderoth, Jeff, James Luedtke, Luedtke, Jim, Luedtke, James, Sridhar, Srikrishna, Srikrishna Sridhar, Jeff Linderoth   +6 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

On the indicator of weak sustainability

, 1995
Facing the difficulties of measuring sustainability, Pearce and Atkinson proposed the Pearce-Atkinson (P-A) indicator, which provides an important direction or method of sustainability measurement.
Zhao Jingzhu, Jingzhu, Verbruggen, H.; id_orcid, Verbruggen, H., Kuik, O., Opschoor, J. B., Jansen, H., Kuik, O.; id_orcid   +6 more
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A hybrid Data Quality Indicator and statistical method for improving uncertainty analysis in LCA of a small off-grid wind turbine

, 2014
In Life Cycle Assessment (LCA) uncertainty analysis has been recommended when choosing sustainable products. Both Data Quality Indicator and statistical methods are used to estimate data uncertainties in LCA.
Ozoemena, Matthew, Hasan, Reaz, Cheung, Wai Ming, Hackney, Philip   +3 more
core