Results 111 to 120 of about 1,134,722 (269)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

2000 Performance Indicators

open access: yes, 2008
149 p. Original html format, a compilation of 12 individual 2000 Performance Indicators reports, was converted to a single pdf ...
University of Oregon. Budget and Resource Planning
core  

Metadata results performance indicators

open access: yes
Additional file 4 (Pdf) contains the results of the performance indicators as published.
Isaura Wayop (Utrecht University)
core   +1 more source

Arizona's use of renewable energy : 15 percent by 2025 [PDF]

open access: yes, 2014
: As Arizona’s population continues to grow, so does the need for electricity. Retail sales of electricity in Arizona have increased along with the population, although sales per person have declined since peaking in 2007, a sign of decreased use and ...

core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Impact--child care assistance programs [PDF]

open access: yes, 2011
: Governor Jan Brewer signed into law the Fiscal 2012 budget that eliminates all child care subsidies in Arizona. While the full impact of that action won’t be felt for weeks and months after the law takes effect July 1, Budget Trax has measured what ...

core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Selection and modeling sustainable urbanization indicators: A responsibility-based method

open access: yes, 2015
The responsibility borne by governmental departments measured by a set of indicators is a key factor affecting the performance of urban sustainability. Thus, responsibility analysis can guide the selection of sustainability indicators.
Song, Xiangnan   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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