Results 161 to 170 of about 4,810,563 (312)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A One Health performance evaluation system for urban parasitic disease prevention and control: The Shanghai, China pilot scheme. [PDF]

One Health
Zhang X, Dong X, Liu X, Wei Z, Liu Y, Chen M, Hao Y, Sun J, Zhou X, Yu Q, Li S.   +10 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The state of innovation in South Africa: Findings from the South African National Innovation Survey

South African Journal of Science, 2012
Cheryl Moses, Moses Sithole, William Blankley, Demetre Labadarios, Hlamulo Makelane, Nolitha Nkobole   +5 more
doaj  

The development of a performance evaluation index system for internet hospitals in Qingdao, China: A Delphi consensus study. [PDF]

SAGE Open Med
Cui N, Sun J, Sui X, Ma P, Sun J, Baloch Z, Cui J.   +6 more
europepmc   +1 more source

Research output indicators are not productivity indicators [PDF]

Journal of Informetrics, 2016
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Patterns and quality of therapeutic care for glioma: a population-based study in Belgium between 2016 and 2019. [PDF]

ESMO Open
Vanhauwaert D, Vanschoenbeek K, Silvermit G, Lombard A, Liefhooghe N, Lammens M, Dedeurwaerdere F, Whenham N, De Gendt C, Boterberg T, De Vleeschouwer S.   +10 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

TAME indicators in Kadorih [PDF]

, 2013
Inagaki, Kazuya
core