Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A report on Canada's progress towards a national set of environmental indicators
, 1991 Environmental indicators are important tools for translating quantities of environmental data into succinct information that can be readily understood and used by decision makers and the general public.
Indicators Task Force, Environment Canada
core
Mapping Quality Indicators in Primary Health Care: A Scoping Review of Contemporary Approaches and Persistent Measurement Gaps. [PDF]
Healthcare (Basel)Triantafyllou C +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Leading Indicators of Inflation for Brazil [PDF]
The goal of this project is to construct leading indicators that anticipate inflation cycle turning points on a real time monitoring basis. As a first step, turning points of the IPCA inflation are determined using a periodic stochastic Markov switching ...
Marcelle Chauvet
core
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
The state of innovation in South Africa: Findings from the South African National Innovation Survey
South African Journal of Science, 2012 Cheryl Moses +5 more
doaj
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Performance indicators and health promition targets [PDF]
This paper discusses the usefulness of performance indicators in health promotion. Health promotion and target-setting in health have both risen to the fore in the light of the Health of the Nation White Paper.
David Buck +2 more
core
Multisource Early Warning Framework Integrating Regional Pathogen Surveillance and Baidu Index Data for Respiratory Infectious Disease Prediction in Beijing: Retrospective Time-Series Modeling Study. [PDF]
JMIR Form ResLiu Y, Gao Y, Du J, Shi Y, Hu X, Li G.
europepmc +1 more source