Results 151 to 160 of about 2,689,332 (309)

A report on Canada's progress towards a national set of environmental indicators

, 1991
Environmental indicators are important tools for translating quantities of environmental data into succinct information that can be readily understood and used by decision makers and the general public.
Indicators Task Force, Environment Canada
core  

Indicator Development for the Evaluation of User-Researcher Collaboration in Health Research: A Co-Designed, Modified Delphi-Study. [PDF]

Health Expect
Verweij L, Safford J, Oesch S, Kohler M, Zurbrügg T, Brülhart T, Jourdan M, Marinello CB, Naef R.   +8 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Beyond global comparability: why universal health coverage indicators must reflect national contexts. [PDF]

J Glob Health
Osawa E.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Comparative assessment of two participatory approach methods for selecting pig health indicators: A proof-of-concept on respiratory health. [PDF]

PLoS One
Dessier T, Millar N, Suazo E, Tallet C, Belloc C, Leblanc-Maridor M.   +5 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Monitoring childbirth and immediate postpartum care quality: A scoping review of indicators in high-income countries. [PDF]

PLoS One
Warren MA, Hamparsoumian D, Lorthe E, Cattani G, Barcos Munoz F, Baud D, Daelemans C, De Vries P, Epiney M, Gerhard E, Hodel M, Loghi M, Martinez De Tejada B, MacSTravic R, Mosimann B, Philibert M, Rihs TA, Steiner A, Gaucher L, Desplanches T.   +19 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Literature Review of Frameworks for Macro-indicators [PDF]

There has been an explosion of interest in recent years in Canada and other countries in macro-indicators and composite indexes of economic and social well-being. This reflects growing recognition of the important role macro-indicators can play as a tool
Andrew Sharpe
core