Results 131 to 140 of about 147,043 (351)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Label-free assessment of complement-dependent cytotoxicity of therapeutic antibodies via a whole-cell MALDI mass spectrometry bioassay

Scientific Reports
Potency assessment of monoclonal antibodies or corresponding biosimilars in cell-based assays is an essential prerequisite in biopharmaceutical research and development.
Stefan Schmidt, Alexander Geisel, Thomas Enzlein, Björn C. Fröhlich, Louise Pritchett, Melanie Verneret, Christian Graf, Carsten Hopf   +7 more
doaj   +1 more source

Paper Chromatography of 2-Halogenated Carboxylic Acids : N,N-Dimethyl-p-phenylazoaniline as an Acid-Base Indicator Reagent [PDF]

, 1962
R. W. Meikle
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

[Effectiveness of erythrocytic diagnostic reagents in indicating Shigellae].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1983
The possibility of the preparation of dysentery antibody diagnostic reagents on the basis of adsorbed sera is shown. Such diagnostic reagents permit to determine 200000-600000 microbial bodies or 0.0008-0.0016 microgram of the antigen per ml. The use of antigenic erythrocytic diagnostic reagents for the indication of shigellae is expedient in the ...
M Iu, Suslova, V A, Shamardin
openaire   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Investigation of the Uniformity of Gel Shrinkage by Imaging Tracer Particles Using X‐Ray Microtomography

Advanced Engineering Materials, EarlyView., 2023
A novel method for tracking structural changes in gels using widely accessible microcomputed tomography is presented and validated for various hydro‐, alco‐, and aerogels. The core idea of the method is to track positions of micrometer‐sized tracer particles entrapped in the gel and relate them to the density of the gel network.
Anja Hajnal, Mimololorun Lucy Aiyelari, Martin Dirauf, Pavel Gurikov   +3 more
wiley   +1 more source

Visceral leishmaniasis control actions: epidemiological indicators for its effectiveness evaluation in a Brazilian urban area

Cadernos de Saúde Pública
: This research applies indicators concerning control of the visceral leishmaniasis canine reservoir in the city of Belo Horizonte, Minas Gerais State, Brazil.
Maria Helena Franco Morais, Paulo Chagastelles Sabroza, José Eduardo Pessanha, Andrea Sobral   +3 more
doaj   +1 more source

A Laboratory Manual for the Preparation of Chemical Reagents, Solutions and Special Indicators

, 2021
Yiglet Mebrat
openalex   +1 more source

Glucose and hemoglobin as factors influencing the reproductive capacity of cattle

Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies
Dairy and meat cattle breeding plays a key role in modern society, providing people with raw materials obtained from cattle in the form of primary or secondary products.
L. V. Klimkovetska, V. I. Karpovskyi, B. Gutyj, I. Hryshchuk, V. Postoi, V. V. Karpovskyi   +5 more
semanticscholar   +1 more source