Results 131 to 140 of about 84,912 (298)

Obtaining drill reagents by modification of neutral-sulphite alkali phosphonic compounds

, 2017
Актуальность работы обусловлена задачей создания низкотоксичных, биоразлагаемых и недорогих реагентов для химической обработки буровых промывочных жидкостей на водной основе.
Ismakov, Rustem Adipovich, Dikhtyar, Tatiana Dmitrievna, Konesev, Gennady Vasilievich, Кантор, Евгений Абрамович, Конесев, Геннадий Васильевич, Дихтярь, Татьяна Дмитриевна, Тептерева, Галина Алексеевна, Teptereva, Galina Alekseevna, Исмаков, Рустэм Адипович, Kantor, Eugeny Abramovich   +9 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Cytokine profile and intracellular matrix component degradation indicators in male ejaculate with chronic urethritis before and following the treatment

, 2020
Aim: The present study was aimed to identify the local level alterations in pro-inflammatory, anti-inflammatory cytokines, and matrix metalloproteinase indicators as well as their tissue inhibitors in male ejaculate with chronic urethritis. Materials and
Tulupova M.S., Hamoshina M.B., Mizanova V.Zh., Karaulov A.V., Zhdanova O.L., Ivanjuk N.A., Sergeevna C.N., Markelova E.V., Nevezhkina T.A.   +8 more
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Review on Detection Methods of Chemical Oxygen Demand in Water Bodies

Yankuang ceshi, 2013
COD is regarded as an important index for representing the degree of organic pollution in water bodies, which has attracted wide attention. The water quality of 10.2% of the 972 state-controlled sections exceeded Ⅴ class among ten water areas such as the
LUO Guo-bing
doaj  

Testing of a Reagent Kit “TEST-NRAS-TISSUE” to Determine Indications for Targeted Therapy in Patients [PDF]

Advances in Health Sciences Research, 2022
Olga Gulenko, Alexey Nikitin, Denis Viktorov, Olga Pavlova, Andrey Toropovskiy   +4 more
openaire   +1 more source