Results 31 to 40 of about 161,117 (167)

Rapid and Integrated Quality Assessment of Organic-Inorganic Composite Herbs by FTIR Spectroscopy—Global Chemical Fingerprints Identification and Multiple Marker Components Quantification of Indigo Naturalis (Qing Dai) [PDF]

Molecules, 2018
This research aimed to develop an FTIR-based method for rapid and low-cost integrated quality assessment of organic-inorganic composite herbs, which are kinds of herbs composed of both organic and inorganic active ingredients or matrix components.
Meng Pan, Wenxuan Pei, Yixin Yao, Ling Dong, Jianbo Chen   +4 more
doaj   +2 more sources

Efficacy of indigo naturalis nanofibrous patches in the treatment of chronic plaque psoriasis: a 4-week prospective, randomized, semi-compartmental paired, positive drug-controlled trial [PDF]

Frontiers in Pharmacology
BackgroundIndigo Naturalis (IN) has been traditionally used for psoriasis treatment. We developed an IN-poly (ε -caprolactone, PCL)/poly (ethylene oxide, PEO) nanofibrous patch using electrospinning technology.
Yuechun Zhao, Jiaqi Li, Ningxin Zhang, Mingyue Liu, Pengyu Wang, Ning Li, Ruodan Xu, Ping Song   +7 more
doaj   +2 more sources

Comparison of the anti-colitis activities of Qing Dai/Indigo Naturalis constituents in mice

Journal of Pharmacological Sciences, 2020
Qing Dai/Indigo Naturalis (QD) has been shown to ameliorate ulcerative colitis (UC) in clinical trials; however, its mechanism remains elusive. This study investigates the effects of QD on murine dextran sulfate sodium salt-induced colitis.
Kei Ozawa, Daichi Mori, Ayumu Hatanaka, Toshinori Sawano, Jin Nakatani, Yukinobu Ikeya, Mikio Nishizawa, Hidekazu Tanaka   +7 more
doaj   +3 more sources

Indigo naturalis‑associated ischemic injury of colorectal mucosa: A case series study. [PDF]

Exp Ther Med
Indigo naturalis, a traditional Chinese herbal medicine characterized by its dark blue hue, is utilized in the treatment of a diverse array of diseases, including ulcerative colitis, psoriasis, oral ulcers, radiation proctitis, chronic myelocytic leukemia and herpes zoster.
Ke Y, Xu L, Tang Q, Ruan Z, Liu J, Ruan S.   +5 more
europepmc   +3 more sources

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science
Many plant‐derived bioactive molecules with low solubility and permeability can cause hepatocyte injury. However, the mechanism by which they induce hepatic damage without passive diffusion into the hepatic circulatory system remains unclear.
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
doaj   +2 more sources

Efficacy and safety of short-term therapy with indigo naturalis for ulcerative colitis: An investigator-initiated multicenter double-blind clinical trial. [PDF]

PLoS ONE, 2020
IntroductionIndigo naturalis (IN) is a blue pigment extracted from Assam indigo and other plants and has been confirmed to be highly effective for ulcerative colitis (UC) treatment in several clinical studies.ObjectiveWe conducted a multicenter double ...
Kan Uchiyama, Shinichiro Takami, Hideo Suzuki, Kiyotaka Umeki, Satoshi Mochizuki, Nobushige Kakinoki, Junichi Iwamoto, Yoko Hoshino, Jun Omori, Shunji Fujimori, Akinori Yanaka, Yuji Mizokami, Toshifumi Ohkusa   +12 more
doaj   +2 more sources

Arsenic trioxide versus Realgar-Indigo naturalis formula in non-high-risk acute promyelocytic leukemia: a multicenter, randomized trial [PDF]

Haematologica
Realgar-Indigo Naturalis Formula (RIF) is an oral form of arsenic that is effective against acute promyelocytic leukemia (APL). This multicenter, randomized, controlled trial compared the efficacy of all-trans retinoic acid (ATRA) plus RIF with ATRA ...
Shu Chen, Weiwei Qin, Xiaohong Lu, Li Liu, Yinsuo Zheng, Xinhua Lu, Xiaohui Wang, Xiaojuan Zhang, Sha Gong, Suhua Wei, Huiyun Zhang, Hanru Ding, Ranjbarha Seifollah, Jing Li, Haitao Zhang, Di Wu, Olubukola Abiona, Pengcheng He, Rong Zhang, David Wald, Huaiyu Wang   +20 more
doaj   +2 more sources

Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis [PDF]

Gastroenterology, 2018
Indigo naturalis (IN) is a traditional Chinese medicine that contains ligands for the aryl hydrocarbon receptor and promotes regeneration of the mucosa by inducing production of interleukin 22. IN might induce mucosal healing in patients with ulcerative colitis (UC).
Takayuki Yamamoto, Akira Andoh, Masahira Hattori   +2 more
exaly   +3 more sources

Qingdainone, a novel bioactive compound in Realgar‒Indigo naturalis, induced apoptosis and differentiation in ATRA‐sensitive and ‐resistant acute promyelocytic leukaemia cells

Clinical and Translational Discovery
Acute promyelocytic leukaemia (APL) is a subtype of acute myeloid leukaemia with high mortality rates. The Realgar‒Indigo naturalis formula (RIF), a traditional Chinese medicine, shows promise in APL treatment, but its mechanisms remain unclear.
Pengcheng Xu, Yang Ou, Xin Tan, Lili Ji, Yanxia Zhan, Pu Chen, Hao Chen, Yunfeng Cheng   +7 more
doaj   +2 more sources

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice. [PDF]

J Appl Toxicol
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Kim HJ, Yang G, Lee JH.
europepmc   +2 more sources