Results 101 to 110 of about 63,783 (328)

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Circularly Polarized Luminescent and Melt‐Processable Copper(I)‐Organic Glasses Based on 2,2′‐Bis(diphenylphosphino)‐1,1′‐binaphthyl

Angewandte Chemie, EarlyView.
Homochiral Cu(I) cyanide complexes based on 2,2’‐bis(diphenylphosphino)‐1,1’‐binaphthyl (BINAP) form melt‐quenched and desolvation‐derived metal–organic glasses that exhibit circularly polarized thermally activated delayed fluorescence (TADF) at room temperature, enabling processable chiroptical materials.
Zeyu Fan, Indranil Sen, Roman Pallach, Guo‐Qiang Li, Andreas Steffen, Sebastian Henke   +5 more
wiley   +2 more sources

Comparison of basal metabolic rate in individuals with a spinal cord injury and Harris-Benedict equation: a systematic review

Acta Universitatis Carolinae Kinanthropologica, 2019
Tables for calculating the energy expenditure of the physical activities of the general population cannot be used due to the different paralysis of the upper or lower limbs in people with spinal cord injury (SCI). The purpose of this review is to compare
Eva Chaloupková, Ivana Kinkorová, Jan Heller   +2 more
doaj   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Giant and reversible extrinsic magnetocaloric effects in La0.7Ca0.3MnO3 films due to strain

, 2012
Large thermal changes driven by a magnetic field have been proposed for environmentally friendly energy efficient refrigeration, but only a few materials which suffer hysteresis show these giant magnetocaloric effects. Here we create giant and reversible
Berger, A., Defaÿ, E., Dhesi, S. S., Ducati, C., Ghidini, M., Hovorka, O., Hueso, L. E., Maccherozzi, F., Mathur, N. D., Moya, X., Phillips, L. C., Podyalovskii, D. I., Tovstolytkin, A. I., Vickers, M. E.   +13 more
core   +1 more source

Multiscale understanding of tricalcium silicate hydration reactions [PDF]

, 2017
Tricalcium silicate, the main constituent of Portland cement, hydrates to produce crystalline calcium hydroxide and calcium-silicate-hydrates (C-S-H) nanocrystalline gel. This hydration reaction is poorly understood at the nanoscale.
Cuesta-García, Ana María, Dapiaggi, Monica, García-Aranda, Miguel Ángel, Gómez-de-la-Torre, María de los Ángeles, Londono-Zuluaga, Diana, Sanfélix, Susana G., Santacruz-Cruz, María Isabel, Vallcorba, Oriol, Zea-Garcia, Jesus D.   +8 more
core   +4 more sources

Determination Of Resting Energy Expenditure (REE) By Indirect Calorimetry (IC) Vs Espen Pocket Formula (PF) In Cancer Patients [PDF]

, 2023
I. Machado, Julia Fantim Lopes, Ingrid Marques Mendes, R.B. Carvalho, Ingrid Christyne Ferreira de Sousa   +4 more
openalex   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Experience with using the sensewear BMS sensor system in the context of a health and wellbeing application [PDF]

, 2011
An assessment of a sensor designed for monitoring energy expenditure, activity, and sleep was conducted in the context of a research project which develops a weight management application.
Batista, R., Bults, R., Hermens, H., Jones, V., Widya, I., Wijk, R.A., de   +5 more
core   +3 more sources

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source