Results 131 to 140 of about 61,847 (299)

Engineering Proton Conductive Metal–Organic Glasses Through Secondary Network Formers

Small, EarlyView.
Incorporating secondary network formers enables access to metal–organic glass with tunable structures and properties. This strategy allows systematic control over key metrics, including anhydrous proton conductivities up to 2.6 mS cm−1 at 150°C, a linear increase in glass transition temperature from 11.0°C to 57.4°C, and more than a 200‐fold increase ...
Nattapol Ma, Hideka Ando, Renzhi Ma, Takashi Nakanishi   +3 more
wiley   +1 more source

Disc‐Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery

Small, EarlyView.
This study demonstrates sub‐50 nm solid‐lipid nanoparticles with long‐term stability, high drug loading, and strong tissue compatibility. Disc‐toroid morphology is confirmed and may play a role in cellular interactions, while low cytotoxicity and minimal systemic permeation confirm depot‐like behavior. These nanoparticles represent a versatile platform
Zanelle van Niekerk, Rima Nuwayhid, Stefaniya Gaydarova, Eva Bittrich, Natalia Makarova, Susanne Boye, Christo Tzachev, Jan C. Simon, Sandra Franz, Albena Lederer   +9 more
wiley   +1 more source

A Comparative Study of Directed Energy Deposition‐Arc and Casting: Enhancing Mechanical and Thermal Properties of Hot‐Work Tool Steels

steel research international, EarlyView.
The study investigates the influence of DED‐Arc/M versus casting on the microstructure and material properties of X40CrMoV5‐1 (AISI H13) hot‐work tool steel. DED‐Arc/M yields finer microstructures, superior mechanical strength, and ductility, but slightly reduced thermal conductivity.
Ulf Ziesing, Aaron Berger, Hendric Schaefer, Sebastian Weber, Jonathan Lentz   +4 more
wiley   +1 more source

Influence of Laser Powder‐Based Directed Energy Deposition and Heat Treatment on the Thermal Conductivity of Cold‐Work Tool Steel X65MoCrWV3‐2

steel research international, EarlyView.
The studied X65MoCrWV3‐2 press hardening tool steel, produced via laser‐based direct energy deposition DED‐LB/M, exhibits a 15‐20% lower thermal conductivity than its conventionally produced equivalent when heat‐treated to operational hardness. The microstructural evolution during the employed direct tempering leads to anisotropic thermal transport, as
Julia Hahn, Christoph Escher, Sebastian Weber, Santiago Benito   +3 more
wiley   +1 more source

Adding arterial nitrogen pressure to single‐measurement monitoring data enables diagnostic lung modeling by deep learning

Physiological Reports
We investigated whether including arterial pressure of nitrogen (PaN2) in a deep‐learning analysis of single measurements of arterial blood gases, cardiac output, and indirect calorimetry enables individualized quantification of West's ventilation ...
Peter H. Scott, Christopher M. Anstey, Thomas J. Morgan   +2 more
doaj   +1 more source

Lithic analysis in African archaeology: Advances and key themes

Archaeometry, EarlyView.
Abstract Stone artifacts (lithics) preserve for extended periods; thus they are key evidence for probing the evolution of human technological behaviors. Africa boasts the oldest record of stone artifacts, spanning 3.3 Ma, rare instances of ethnographic stone tool‐making, and stone tool archives from diverse ecological settings, making it an anchor for ...
Deborah I. Olszewski, Amanuel Beyin, Justin Pargeter   +2 more
wiley   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Intravenous Oxytocin Has no Effect on Ad Libitum Food Intake or Postprandial Plasma Glucose Concentrations in Individuals With Obesity: A Randomised, Placebo‐Controlled, Double‐Blind, Crossover Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Oxytocin is expressed throughout the small intestine, suggesting a role for oxytocin in postprandial metabolism. Accordingly, single‐dose intranasal oxytocin reduces food intake and improves glucose tolerance. We investigated the effects of a continuous intravenous oxytocin infusion on ad libitum food intake, appetite sensations ...
Ida M. Gether, Vivian Kliim‐Hansen, Petur T. Olafsson, Miriam G. Pedersen, Casper K. Nielsen, Anne‐Marie Ellegaard, Mikkel B. Christensen, Jens F. Rehfeld, Jørn W. Helge, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +13 more
wiley   +1 more source

Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 proteins

The FEBS Journal, EarlyView.
Calcium‐binding S100 proteins are important mediators of inflammation in humans. Distant members of this family have been recently discovered in teleost fish but their resemblance to human proteins has not been explored yet. This study demonstrates that zebrafish‐specific S100i1 and S100i2 (ictacalcins) possess identical structural organization and ...
Liz Hernández, Théo Paris, Maria Demou, Catherine Birck, Christina Begon‐Pescia, Juan Francisco Rodríguez Vidal, Sylwia D. Tyrkalska, Charlotte Bureau, Catherine Gonzalez, Juliette Gracia, Etienne Lelièvre, Victoriano Mulero, Mai Nguyen‐Chi, Laure Yatime   +13 more
wiley   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source