Results 131 to 140 of about 1,223,886 (257)

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

A consensus guide to preclinical indirect calorimetry experiments.

Understanding the complex factors influencing mammalian metabolism and body weight homeostasis is a long-standing challenge requiring knowledge of energy intake, absorption and expenditure.
Tiganis, Tony, James, David E, Heymsfield, Steven B., Thyfault, John P, Auwerx, Johan, Hevener, Andrea L., Allison, David B., Austad, Steven N, Wolfrum, Christian, Gerhart-Hines, Zachary, Xu, Ying, de Cabo, Rafael, Medina‐Gómez, Gema, Selloum, Mohammed, Scherer, Philipp E, Grobe, Justin L, Speakman, John R, Spiegelman, Bruce M., Habegger, Kirk M., Ayala, Julio E, Reitman, Marc L, Titchenell, Paul M., Škop, Vojtěch, Ferrante, Anthony W., Speakman, John R., Shulman, Gerald I., Baur, Joseph A, Lo, James C., MacLean, Paul S, Steinberg, Gregory R., Hartig, Sean M, Rensen, Patrick C N, Churchill, Gary A., Banks, Alexander S, de Angelis, Martin Hrabě, Williams, Ashley S., Gupta, Rana K., Ansarullah,, Lodhi, Irfan J., Klingenspor, Martin, Chen, Shuai, Kooijman, Sander, Mirmira, Raghavendra G, Grobe, Justin L., Williams, Ashley S, Carobbio, Stefania, Finck, Brian N., Steinberg, Gregory R, Donato, Jose, Rutkowsky, Jennifer M, Ward, Christopher S, Sedlacek, Radislav, Elias, Carol F, Rensen, Patrick C.N., Soukas, Alexander A, Ward, Christopher, Velloso, Licio A, Allison, David B, Morrison, Christopher D, Müller, Timo D., Elias, Carol F., MacLean, Paul S., Müller, Timo D, Dall, Morten, Potthoff, Matthew J, Vidal-Puig, Antonio, Ferrante, Anthony W, Banks, Alexander S., Rozman, Jan, Morton, Gregory J., Ogawa, Yoshihiro, Reguera, David Pajuelo, Holman, Corey D., Kazak, Lawrence, McGuinness, Owen P, Reitman, Marc L., Hevener, Andrea L, Hartig, Sean M., Velloso, Lı́cio A., Thyfault, John P., Austad, Steven N., Ayala, Julio E., Vidal‐Puig, Antonio, Zierath, Juleen R, Svensson, Katrin J., Mirmira, Raghavendra G., Alquier, Thierry, The International Indirect Calorimetry Consensus Committee (IICCC, Galgani, José E., Churchill, Gary, Potthoff, Matthew J., Morton, Gregory J, Shulman, Gerald I, Spiegelman, Bruce M, Morrison, Christopher D., Lodhi, Irfan J, Sakamoto, Kei, Scherer, Philipp E., Gupta, Rana K, Qi, Nathan, Turner, Nigel, Zierath, Juleen R., Dragano, Nathalia Romanelli Vicente, McGuinness, Owen P., Schwartz, Gary J., Goodyear, Laurie J., Kong, Xingxing, Kim, Jae Bum, Holman, Corey D, Rutkowsky, Jennifer M., Shaikh, Saame Raza, Svensson, Katrin J, Xu, Allison, Medina-Gómez, Gema, Gerhart‐Hines, Zachary, Goodyear, Laurie J, Habegger, Kirk M, Galgani, Jose E, Pajuelo-Reguera, David, Lantier, Louise, Finck, Brian N, James, David E., Baur, Joseph A., Dragano, Nathalia R V, Schwartz, Gary J, Heymsfield, Steven B, Lo, James C, Lloyd, K C Kent, Soukas, Alexander A., Xu, Allison W, Lloyd, K. C. Kent, Titchenell, Paul M   +131 more
core   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Elisa Lucinda: artigo 227 [Constituindo]

, 2011
Ensino Fundamental Final::Pluralidade CulturalEnsino Fundamental::Séries Iniciais::Pluralidade CulturalApresenta vídeo da série Constituindo. Neste episódio a atriz Elisa Lucinda lê o artigo 227 da Constituição Federal do Brasil de 1988.
TV Câmara
core   +1 more source