Results 21 to 30 of about 325,935 (288)

Systematic inference of indirect transcriptional regulation by protein kinases and phosphatases.

open access: yesPLoS Computational Biology, 2022
Gene expression is controlled by pathways of regulatory factors often involving the activity of protein kinases on transcription factor proteins. Despite this well established mechanism, the number of well described pathways that include the regulatory ...
Christian Degnbol Madsen   +2 more
doaj   +1 more source

Accurate determination of causalities in gene regulatory networks by dissecting downstream target genes

open access: yesFrontiers in Genetics, 2022
Accurate determination of causalities between genes is a challenge in the inference of gene regulatory networks (GRNs) from the gene expression profile.
Zhigang Jia   +3 more
doaj   +1 more source

Ensemble inference and inferability of gene regulatory networks. [PDF]

open access: yesPLoS ONE, 2014
The inference of gene regulatory network (GRN) from gene expression data is an unsolved problem of great importance. This inference has been stated, though not proven, to be underdetermined implying that there could be many equivalent (indistinguishable)
S M Minhaz Ud-Dean, Rudiyanto Gunawan
doaj   +1 more source

Constraining effective field theories with machine learning [PDF]

open access: yesEPJ Web of Conferences, 2020
An important part of the Large Hadron Collider (LHC) legacy will be precise limits on indirect effects of new physics, framed for instance in terms of an effective field theory.
Brehmer Johann   +6 more
doaj   +1 more source

Neural nets for indirect inference [PDF]

open access: yesEconometrics and Statistics, 2021
For simulable models, neural networks are used to approximate the limited information posterior mean, which conditions on a vector of statistics, rather than on the full sample. Because the model is simulable, training and testing samples may be generated with sizes large enough to train well a net that is large enough, in terms of number of hidden ...
  +11 more sources

Indirect effect inference and application to GAW20 data

open access: yesBMC Genetics, 2018
Background Association studies using a single type of omics data have been successful in identifying disease-associated genetic markers, but the underlying mechanisms are unaddressed.
Liming Li   +4 more
doaj   +1 more source

RENGE infers gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations

open access: yesCommunications Biology, 2023
Single-cell RNA-seq analysis coupled with CRISPR-based perturbation has enabled the inference of gene regulatory networks with causal relationships.
Masato Ishikawa   +12 more
doaj   +1 more source

A general model-based causal inference method overcomes the curse of synchrony and indirect effect

open access: yesNature Communications, 2023
To identify causation, model-free inference methods, such as Granger Causality, have been widely used due to their flexibility. However, they have difficulty distinguishing synchrony and indirect effects from direct causation, leading to false ...
Se Ho Park, Seokmin Ha, Jae Kyoung Kim
doaj   +1 more source

Causal inference from indirect experiments [PDF]

open access: yesArtificial Intelligence in Medicine, 1995
An indirect experiment is a study in which randomized control is replaced by randomized encouragement, that is, subjects are encouraged, rather than forced, to receive a given treatment program. The purpose of this paper is to bring to the attention of experimental researchers simple mathematical results that enable us to assess, from indirect ...
openaire   +3 more sources

Ibn Sina's concept of contradiction

open access: yesآداب الكوفة, 2015
This research talks about the concept of inference (inference) according to what those concerned with this science know, as the research dealt with the concept of inference linguistically and idiomatically, and the research also divided inference into ...
جواد الساعدي   +1 more
doaj   +1 more source

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