Results 1 to 10 of about 606,063 (83)

Plugging Small RNAs into the Network

mSystems, 2020
Small RNAs (sRNAs) have been discovered in every bacterium examined and have been shown to play important roles in the regulation of a diverse range of behaviors, from metabolism to infection.
Lars Barquist
doaj   +3 more sources

Inferring microbial co-occurrence networks from amplicon data: a systematic evaluation

mSystems, 2023
Microbes commonly organize into communities consisting of hundreds of species involved in complex interactions with each other. 16S ribosomal RNA (16S rRNA) amplicon profiling provides snapshots that reveal the phylogenies and abundance profiles of these
Dileep Kishore, Gabriel Birzu, Zhenjun Hu, Charles DeLisi, Kirill S. Korolev, Daniel Segrè   +5 more
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Identifiability of complex networks

Frontiers in Physics, 2023
We discuss the core principles underpinning the concept of identifiability, providing an overview of relevant literature concerning this phenomenon within the domain of complex networks.
M. Zanin, J. M. Buldú, J. M. Buldú
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Exploration of Blood Metabolite Signatures of Colorectal Cancer and Polyposis through Integrated Statistical and Network Analysis

Metabolites, 2023
Colorectal cancer (CRC), one of the most prevalent and deadly cancers worldwide, generally evolves from adenomatous polyps. The understanding of the molecular mechanisms underlying this pathological evolution is crucial for diagnostic and prognostic ...
Francesca Di Cesare, Alessia Vignoli, Claudio Luchinat, Leonardo Tenori, Edoardo Saccenti   +4 more
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Corynebacterium glutamicum Regulation beyond Transcription: Organizing Principles and Reconstruction of an Extended Regulatory Network Incorporating Regulations Mediated by Small RNA and Protein–Protein Interactions

Microorganisms, 2021
Corynebacterium glutamicum is a Gram-positive bacterium found in soil where the condition changes demand plasticity of the regulatory machinery. The study of such machinery at the global scale has been challenged by the lack of data integration. Here, we
Juan M. Escorcia-Rodríguez, Andreas Tauch, Julio A. Freyre-González   +2 more
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Modular network inference between miRNA–mRNA expression profiles using weighted co-expression network analysis

Journal of Integrative Bioinformatics, 2021
Connecting transcriptional and post-transcriptional regulatory networks solves an important puzzle in the elucidation of gene regulatory mechanisms. To decipher the complexity of these connections, we build co-expression network modules for mRNA as well ...
Wani Nisar, Barh Debmalya, Raza Khalid
doaj   +1 more source

Accurate determination of causalities in gene regulatory networks by dissecting downstream target genes

Frontiers in Genetics, 2022
Accurate determination of causalities between genes is a challenge in the inference of gene regulatory networks (GRNs) from the gene expression profile.
Zhigang Jia, Zhigang Jia, Xiujun Zhang, Xiujun Zhang   +3 more
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Evaluating the Reproducibility of Single-Cell Gene Regulatory Network Inference Algorithms

Frontiers in Genetics, 2021
Networks are powerful tools to represent and investigate biological systems. The development of algorithms inferring regulatory interactions from functional genomics data has been an active area of research.
Yoonjee Kang, Denis Thieffry, Laura Cantini   +2 more
doaj   +1 more source

High-Dimensional Bayesian Network Inference From Systems Genetics Data Using Genetic Node Ordering

Frontiers in Genetics, 2019
Studying the impact of genetic variation on gene regulatory networks is essential to understand the biological mechanisms by which genetic variation causes variation in phenotypes. Bayesian networks provide an elegant statistical approach for multi-trait
Lingfei Wang, Lingfei Wang, Lingfei Wang, Pieter Audenaert, Pieter Audenaert, Tom Michoel, Tom Michoel   +6 more
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Network Embedding Across Multiple Tissues and Data Modalities Elucidates the Context of Host Factors Important for COVID-19 Infection

Frontiers in Genetics, 2022
COVID-19 is a heterogeneous disease caused by SARS-CoV-2. Aside from infections of the lungs, the disease can spread throughout the body and damage many other tissues, leading to multiorgan failure in severe cases. The highly variable symptom severity is
Yue Hu, Yue Hu, Ghalia Rehawi, Ghalia Rehawi, Lambert Moyon, Nathalie Gerstner, Nathalie Gerstner, Christoph Ogris, Janine Knauer-Arloth, Janine Knauer-Arloth, Florian Bittner, Annalisa Marsico, Nikola S. Mueller, Nikola S. Mueller   +13 more
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