Results 41 to 50 of about 2,359,696 (278)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Pulsewidth Modulation of Neutral-Point-Clamped Indirect Matrix Converter

, 2008
An indirect matrix converter is an alternative "all-semiconductor" energy processor proposed recently for converting an ac source with fixed magnitude and frequency to a variable voltage and frequency supply that can meet the requirements of a particular
Blaabjerg, Frede; id_orcid, Gao, Feng, Baby, Anto, Tan, Desmond Aik Chuan, Poh Chiang, Loh   +4 more
core   +1 more source

A hybrid multilevel converter for medium and high voltage applications [PDF]

, 2010
This paper investigates the suitability of the hybrid multilevel converter for medium and high voltage application. The converter operation, modulation, and capacitor voltage balancing method are described in detail.
Ahmed, Khaled, Adam, Grain Philip, Finney, Stephen, Singh, N.K., Williams, Barry   +4 more
core   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Fuzzy Fractional-Order PID Control for PMSG Based Wind Energy Conversion System with Sparse Matrix Converter Topology

International Transactions on Electrical Energy Systems, 2022
Sparse matrix converter (SMC) is an indirect AC-to-AC power electronic converter that has a fictitious DC link between rectification and inversion stages in which neither a capacitor nor an inductor, as the storage element, is utilized.
Waleed Khaled Abdulrazaq Abdulrazaq, Ahmet Mete Vural   +1 more
doaj   +1 more source

Imposed Sinusoidal Source and Load Currents for an Indirect Matrix Converter

IEEE Transactions on Industrial Electronics, 2012
A new strategy for indirect matrix converters which allows an optimal control of source and load currents is presented in this paper. This method uses the commutation state of the converter in the subsequent sampling time according to an optimization algorithm given by a simple cost functional and the discrete system model.
Rivera, Marco, Rodriguez, Jose, Espinoza, Jose R., Friedli, Thomas, Kolar, Johann W., Wilson, Alan, Rojas, Christian A.   +6 more
openaire   +3 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source