Results 41 to 50 of about 2,066 (253)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Dynamic Voltage Restorer based on Matrix Converter with Fuzzy Controller

Advances in Electrical and Electronic Engineering, 2012
In this paper, a Dynamic Voltage Restorer (DVR) without any energy storage devices is proposed to compensate network voltage during disturbances. This DVR utilizes a matrix converter in its topology which eliminates the DC-link capacitor of conventional ...
Amin Shabanpour, Ali Reza Seifi
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Fuzzy Fractional-Order PID Control for PMSG Based Wind Energy Conversion System with Sparse Matrix Converter Topology

International Transactions on Electrical Energy Systems, 2022
Sparse matrix converter (SMC) is an indirect AC-to-AC power electronic converter that has a fictitious DC link between rectification and inversion stages in which neither a capacitor nor an inductor, as the storage element, is utilized.
Waleed Khaled Abdulrazaq Abdulrazaq, Ahmet Mete Vural   +1 more
doaj   +1 more source

Imposed Sinusoidal Source and Load Currents for an Indirect Matrix Converter

IEEE Transactions on Industrial Electronics, 2012
A new strategy for indirect matrix converters which allows an optimal control of source and load currents is presented in this paper. This method uses the commutation state of the converter in the subsequent sampling time according to an optimization algorithm given by a simple cost functional and the discrete system model.
Rivera, Marco, Rodriguez, Jose, Espinoza, Jose R., Friedli, Thomas, Kolar, Johann W., Wilson, Alan, Rojas, Christian A.   +6 more
openaire   +3 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

A New Three-Level Sparse Indirect Matrix Converter [PDF]

IECON 2006 - 32nd Annual Conference on IEEE Industrial Electronics, 2006
Matrix converters are forced commutated single stage AC/AC direct frequency changers able to achieve sine wave in and out operation by being able to connect any input phase to any output phase via a 3times3 matrix of bi-directional switches. Indirect two-stage matrix converters provide similar input and output performance with no passive component in ...
Christian Klumpner, Meng Lee, Patrick Wheeler   +2 more
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source