Results 91 to 100 of about 722,268 (215)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Numerical investigations on constitutive model parameters of HRB400 and HTRB600 steel bars based on tensile and fatigue tests

Reviews on Advanced Materials Science
In recent years, HRB400 and HTRB600 steel bars have become the mainstream standard reinforcing steel used in concrete structures in China. However, significant controversy still exists regarding the selection of material constitutive models and the ...
Zhu Hanbo, Deng Jibing, Zhuang Mei-Ling, Sun Chuanzhi, Gao Li, Shao Yuefeng, Wang Mingsen, Wang Youzhi, Dong Yao-Rong, Tong Lei   +9 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Intuitive web tools for reference interval estimation: goCrunch and ReferenceRangeR

Journal of Laboratory Medicine
Verification of reference intervals (RIs) is mandatory for clinical laboratories. In this context indirect methods of RI estimation may be of assistance, yet these are often limited to experts with programming or statistical skills due to the lack of ...
Arslan Fatma Demet, Farrell Christopher-John Lancaster, Brandhorst Gunnar, Voss Maike, Yazıcı Güvercin Ayşe Canan   +4 more
doaj   +1 more source

Derivation of transformed stress method based on indirect thermodynamic method

Yantu gongcheng xuebao
The unique plastic potential function consistent with the yield function can be directly determined by the Drucker's postulate and its associated flow law deduction after the yield function is established for the continuous materials without dilatancy ...
YAO Yangping 1, HE Guan 2, CUI Wenjie 1
doaj   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Cardiac magnetic resonance systematically overestimates mitral regurgitations by the indirect method. [PDF]

Open Heart, 2020
Bertelsen L, Vejlstrup N, Andreasen L, Olesen MS, Svendsen JH.   +4 more
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source