Results 91 to 100 of about 185,612 (294)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

A meshless Hierarchical Representation for Light Transport

open access: yes, 2008
International audienceWe introduce a meshless hierarchical representation for solving light transport problems. Precomputed radiance transfer (PRT) and finite elements require a discrete representation of illumination over the scene.
Matthias Zwicker   +13 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

THE REPRESENTATION OF INDONESIAN WOMEN IN JAKARTA POST ARTICLES THROUGH THE TYPES OF INDIRECT SEXISM [PDF]

open access: yes, 2017
This study aims to discover the representation of Indonesian women in Jakarta Post articles. The representation is drawn through the occurrence of types of indirect sexism.
ANITA MARET PRASETYOWATI, 121511223015
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Salience Criteria of Indirect Non-Entrenched Textual Names in Russian: Corpus-Based Research

open access: yesRussian journal of linguistics: Vestnik RUDN, 2019
The article approaches textual foreground specifics of indirect non-entrenched names and nominal groups in the Russian language. These constructions reveal the results of particular focus shifts with both identifying and characterizing or classifying ...
Maria Ivanovna Kiose
doaj   +1 more source

Monoamine Oxidase Inhibitors – Indirect Acting Sympathomimetics - contextualized potential drug-drug interaction clinical algorithm

open access: yes, 2018
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between Monoamine Oxidase Inhibitors – Indirect Acting Sympathomimetics. The information is not advice, and should not be treated as such. The information is
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Le discours indirect libre comme patron de la prose fictionnelle de la première modernité (XVIIe-XVIIIe siècles)

open access: yesSHS Web of Conferences, 2018
L’étiquette de discours indirect libre existe depuis la fin du XIXe siècle, au moment où cette forme est repérée dans des textes fictionnels de la même époque.
Duval Suzanne
doaj   +1 more source

Does the representation of household behavior matter for welfare analysis of tax-benefit policies? : an introduction. [PDF]

open access: yes
A widely shared intuition holds that individual control over money matters for the decision process within the household and the subsequent distribution of resources and welfare.
Laisney, François   +11 more
core  

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